Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression.
Animals
Bone Marrow Cells
/ metabolism
Cell Adhesion
Cell Proliferation
Cells, Cultured
Chimera
Extracellular Matrix
/ metabolism
Female
Fibrosis
Integrins
/ metabolism
Kidney
/ pathology
Leukocyte Common Antigens
/ metabolism
Leukocytes
/ metabolism
Macrophages
/ metabolism
Mice
NF-kappa B
/ metabolism
Nephritis
/ etiology
Receptor, Notch3
/ genetics
Signal Transduction
Transcriptome
Transendothelial and Transepithelial Migration
Ureteral Obstruction
/ complications
cell adhesion
cell signaling
chronic inflammation
chronic kidney disease
fibrosis
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
13
12
2019
accepted:
12
07
2020
pubmed:
30
8
2020
medline:
10
3
2021
entrez:
30
8
2020
Statut:
ppublish
Résumé
Kidney injuries that result in chronic inflammation initiate crosstalk between stressed resident cells and infiltrating immune cells. In animal models, whole-body receptor Chimeric mice deficient for Fibrosis follows UUO, but inflammatory cell infiltration mostly depends upon Notch3 expression in hematopoietic cells, which coincides with an enhanced proinflammatory milieu ( Cell-specific receptor Notch3 signaling independently orchestrates leukocyte infiltration and organ fibrosis. Interference with Notch3 signaling may present a novel therapeutic approach in inflammatory as well as fibrotic diseases.
Sections du résumé
BACKGROUND
Kidney injuries that result in chronic inflammation initiate crosstalk between stressed resident cells and infiltrating immune cells. In animal models, whole-body receptor
METHODS
Chimeric mice deficient for
RESULTS
Fibrosis follows UUO, but inflammatory cell infiltration mostly depends upon Notch3 expression in hematopoietic cells, which coincides with an enhanced proinflammatory milieu (
CONCLUSIONS
Cell-specific receptor Notch3 signaling independently orchestrates leukocyte infiltration and organ fibrosis. Interference with Notch3 signaling may present a novel therapeutic approach in inflammatory as well as fibrotic diseases.
Identifiants
pubmed: 32859670
pii: ASN.2019121289
doi: 10.1681/ASN.2019121289
pmc: PMC7608975
doi:
Substances chimiques
Integrins
0
NF-kappa B
0
Notch3 protein, mouse
0
Receptor, Notch3
0
Leukocyte Common Antigens
EC 3.1.3.48
Ptprc protein, mouse
EC 3.1.3.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2589-2608Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
Références
Nat Rev Nephrol. 2011 Oct 18;7(12):684-96
pubmed: 22009250
Cells Tissues Organs. 2008;188(1-2):170-7
pubmed: 18160825
Nature. 2019 Jan;565(7740):505-510
pubmed: 30651639
Science. 2018 May 18;360(6390):758-763
pubmed: 29622724
J Immunol. 2011 Jun 1;186(11):6199-206
pubmed: 21508258
J Clin Invest. 2010 Nov;120(11):4040-54
pubmed: 20978353
Pediatr Nephrol. 2015 Feb;30(2):199-209
pubmed: 24442822
Genesis. 2003 Nov;37(3):139-43
pubmed: 14595837
J Am Soc Nephrol. 2015 Jul;26(7):1561-75
pubmed: 25421557
Nat Med. 2013 Aug;19(8):1047-53
pubmed: 23817022
Biomolecules. 2019 Apr 08;9(4):
pubmed: 30965656
Nat Commun. 2019 Jun 27;10(1):2832
pubmed: 31249312
Br J Cancer. 2013 Mar 5;108(4):755-61
pubmed: 23322204
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
J Clin Invest. 2019 Mar 26;129(6):2374-2389
pubmed: 30912765
J Immunol. 2010 Oct 1;185(7):3905-12
pubmed: 20810995
Cell. 2010 Mar 19;140(6):821-32
pubmed: 20303873
Kidney Int Suppl (2011). 2014 Nov;4(1):91-96
pubmed: 26312157
J Am Soc Nephrol. 2018 Jul;29(7):1859-1873
pubmed: 29777019
Ren Fail. 2019 Nov;41(1):576-594
pubmed: 31237170
Biochim Biophys Acta. 2013 Jul;1832(7):989-97
pubmed: 23246690
J Clin Invest. 2015 Aug 3;125(8):2935-51
pubmed: 26193634
Hypertension. 2011 Jun;57(6):1176-82
pubmed: 21518968
Mol Aspects Med. 2019 Feb;65:16-36
pubmed: 29909119
Front Immunol. 2019 Apr 16;10:815
pubmed: 31040851
N Engl J Med. 2015 Mar 19;372(12):1138-49
pubmed: 25785971
Curr Opin Lipidol. 2016 Oct;27(5):513-20
pubmed: 27454451
Kidney Int. 2020 Feb;97(2):289-303
pubmed: 31882173
J Pathol. 2013 Nov;231(3):273-89
pubmed: 24006178
J Pathol. 2012 Nov;228(3):286-99
pubmed: 22806125
PLoS Biol. 2018 Sep 18;16(9):e2005233
pubmed: 30226866
Onco Targets Ther. 2013 Jul 23;6:943-55
pubmed: 23901284
Leukemia. 2013 Apr;27(5):1009-18
pubmed: 23307030
Cancer Res. 2009 Jan 15;69(2):458-65
pubmed: 19147558
J Biol Chem. 1995 Nov 3;270(44):26270-7
pubmed: 7592835
J Leukoc Biol. 2008 Dec;84(6):1521-9
pubmed: 18765478
Kidney Int. 2018 Jul;94(1):126-138
pubmed: 29751972
JCI Insight. 2019 Jan 24;4(2):
pubmed: 30674729
Cell. 2010 Mar 19;140(6):871-82
pubmed: 20303877
J Cell Sci. 2016 Dec 1;129(23):4321-4327
pubmed: 27875272
J Am Soc Nephrol. 2017 Mar;28(3):785-801
pubmed: 27612995
Leukemia. 2014 Dec;28(12):2324-35
pubmed: 24727676
Materials (Basel). 2015 Aug 28;8(9):5671-5701
pubmed: 28793529
Cell Stem Cell. 2015 Jan 8;16(1):51-66
pubmed: 25465115
Biochim Biophys Acta. 2013 Jul;1832(7):1049-60
pubmed: 23046809
Annu Rev Physiol. 2018 Feb 10;80:309-326
pubmed: 29068765
Nephrol Dial Transplant. 2002 Jun;17(6):998-1004
pubmed: 12032188
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
JCI Insight. 2017 Sep 21;2(18):
pubmed: 28931758
J Pathol. 2012 Jan;226(2):394-403
pubmed: 21952830
Atherosclerosis. 2018 Nov;278:156-165
pubmed: 30278358
J Clin Invest. 2014 Apr;124(4):1711-22
pubmed: 24614106
Nat Commun. 2017 Oct 16;8(1):952
pubmed: 29038527
Nat Biotechnol. 2006 Oct;24(10):1270-8
pubmed: 17013374
Kidney Int. 2017 Nov;92(5):1157-1177
pubmed: 28610763
Sci Transl Med. 2009 Nov 4;1(5):5ra13
pubmed: 20368175
Circ Res. 2006 Jun 23;98(12):1468-70
pubmed: 16741155
J Clin Invest. 2018 Oct 1;128(10):4359-4371
pubmed: 30024857
Sci Rep. 2016 May 18;6:26235
pubmed: 27189340