First-in-Human Assessment of

Adult Brain / metabolism Female Humans Indoles / adverse effects Kinetics Ligands Male Piperidines / adverse effects Positron-Emission Tomography / adverse effects Radioactive Tracers Radiochemistry Receptor, Muscarinic M1 / metabolism Safety
PET brain imaging muscarinic acetylcholine receptor 1 scopolamine test–retest reproducibility

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
04 2021
Historique:
received: 10 04 2020
accepted: 09 07 2020
pubmed: 30 8 2020
medline: 12 5 2021
entrez: 30 8 2020
Statut: ppublish

Résumé

This was a first-in-human study of the PET radiotracer

Identifiants

DOI: 10.2967/jnumed.120.246967 PMID: 32859711 PMC: PMC8049371
pubmed: 32859711
pii: jnumed.120.246967
doi: 10.2967/jnumed.120.246967
pmc: PMC8049371
doi:

Substances chimiques

Indoles 0
LSN3172176 0
Ligands 0
Piperidines 0
Radioactive Tracers 0
Receptor, Muscarinic M1 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

553-560

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024139
Pays : United States

Informations de copyright

© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Références

Pharmacol Biochem Behav. 1991 Apr;38(4):723-9
pubmed: 1871189
Neuroscience. 1986 Oct;19(2):551-64
pubmed: 3774154
J Nucl Med. 2015 Feb;56(2):243-8
pubmed: 25593119
Med Phys. 2013 Oct;40(10):102503
pubmed: 24089924
Eur J Pharmacol. 1989 Dec 7;173(2-3):133-41
pubmed: 2625133
Med Res Rev. 2019 May;39(3):1014-1052
pubmed: 30450619
J Comput Assist Tomogr. 1998 Mar-Apr;22(2):324-33
pubmed: 9530404
Neuron. 2014 Nov 19;84(4):697-707
pubmed: 25453841
Bull Math Biol. 2019 Sep;81(9):3508-3541
pubmed: 29230702
J Nucl Med. 2004 Apr;45(4):682-94
pubmed: 15073266
J Pharmacol Exp Ther. 1992 Feb;260(2):576-80
pubmed: 1346637
J Chem Neuroanat. 2003 Mar;25(3):161-73
pubmed: 12706204
Nucl Med Biol. 2000 Aug;27(6):627-30
pubmed: 11056380
Neuropsychopharmacology. 2016 Dec;41(13):3042-3050
pubmed: 27374277
Synapse. 1990;5(3):213-23
pubmed: 2343375
EJNMMI Res. 2014 Dec;4(1):66
pubmed: 26116126
Dementia. 1996 Jul-Aug;7(4):187-95
pubmed: 8835881
Behav Pharmacol. 2017 Apr;28(2 and 3-Spec Issue):112-123
pubmed: 28240674
J Cereb Blood Flow Metab. 2010 Jan;30(1):46-50
pubmed: 19738632
J Nucl Med. 2014 Mar;55(3):396-404
pubmed: 24481024
EJNMMI Res. 2013 Mar 21;3(1):19
pubmed: 23514539
Neuroscience. 1987 Jan;20(1):65-107
pubmed: 3561769
ACS Chem Neurosci. 2018 Feb 21;9(2):224-229
pubmed: 29072902
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
J Cereb Blood Flow Metab. 2018 Nov;38(11):2041-2052
pubmed: 28792356
Insight J. 2006;2006:209
pubmed: 25364771
Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):163-81
pubmed: 12769625
J Nucl Med. 2019 Aug;60(8):1147-1153
pubmed: 30733324
Trends Pharmacol Sci. 1995 Mar;16(3):89-97
pubmed: 7540781
Nucl Med Biol. 1995 Jan;22(1):13-7
pubmed: 7735163
J Nucl Med. 2014 Jun;55(6):960-6
pubmed: 24732151
J Pharmacol Exp Ther. 2018 Jun;365(3):602-613
pubmed: 29643252
Brain Res. 1978 Sep 22;153(2):295-306
pubmed: 687983
Eur J Pharmacol. 1992 Mar 24;213(2):275-84
pubmed: 1521561

Auteurs

Mika Naganawa (M)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and mika.naganawa@yale.edu.

Nabeel Nabulsi (N)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

Shannan Henry (S)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

David Matuskey (D)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

Shu-Fei Lin (SF)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

Lawrence Slieker (L)

Eli Lilly and Company, Indianapolis, Indiana.

Adam J Schwarz (AJ)

Eli Lilly and Company, Indianapolis, Indiana.

Nancy Kant (N)

Eli Lilly and Company, Indianapolis, Indiana.

Cynthia Jesudason (C)

Eli Lilly and Company, Indianapolis, Indiana.

Kevin Ruley (K)

Eli Lilly and Company, Indianapolis, Indiana.

Antonio Navarro (A)

Eli Lilly and Company, Indianapolis, Indiana.

Hong Gao (H)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

Jim Ropchan (J)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

David Labaree (D)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

Richard E Carson (RE)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

Yiyun Huang (Y)

PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; and.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › First-in-Human Assessment of
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › First-in-Human Assessment of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › First-in-Human Assessment of
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › First-in-Human Assessment of
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › First-in-Human Assessment of
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › First-in-Human Assessment of
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › First-in-Human Assessment of
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › First-in-Human Assessment of
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Traceurs radioactifs › First-in-Human Assessment of
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie physique › Radiochimie › First-in-Human Assessment of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M1 › First-in-Human Assessment of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Accidents › Prévention des accidents › Sécurité › First-in-Human Assessment of