Dynamic changes in the systemic immune responses of spinal cord injury model mice.

C-reactive protein T-helper cells immune dysfunction inflammation inflammatory cytokines regulatory T-cells spinal cord injury systemic immune response

Journal

Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351

Informations de publication

Date de publication:
Feb 2021
Historique:
entrez: 30 8 2020
pubmed: 30 8 2020
medline: 30 8 2020
Statut: ppublish

Résumé

Intraspinal inflammatory and immune responses are considered to play central roles in the pathological development of spinal cord injury. This study aimed to decipher the dynamics of systemic immune responses, initiated by spinal cord injury. The spinal cord in mice was completely transected at T8. Changes in the in vivo inflammatory response, between the acute and subacute stages, were observed. A rapid decrease in C-reactive protein levels, circulating leukocytes and lymphocytes, spleen-derived CD4

Identifiants

pubmed: 32859802
pii: NeuralRegenRes_2021_16_2_382_290910
doi: 10.4103/1673-5374.290910
pmc: PMC7896203
doi:

Types de publication

Journal Article

Langues

eng

Pagination

382-387

Déclaration de conflit d'intérêts

None

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Auteurs

Tian-Yun Gao (TY)

Clinical Stem Cell Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Fei-Fei Huang (FF)

Clinical Stem Cell Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Yuan-Yuan Xie (YY)

Clinical Stem Cell Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Wen-Qing Wang (WQ)

Clinical Stem Cell Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Liu-Di Wang (LD)

Clinical Stem Cell Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Dan Mu (D)

Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Yi Cui (Y)

Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, China.

Bin Wang (B)

Clinical Stem Cell Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Classifications MeSH