Silica particles incorporated into PLGA-based in situ-forming implants exploit the dual advantage of sustained release and particulate delivery.
Animals
Bone Marrow Cells
/ drug effects
Delayed-Action Preparations
/ administration & dosage
Drug Carriers
/ administration & dosage
Drug Delivery Systems
/ methods
Drug Implants
/ administration & dosage
Drug Liberation
/ physiology
Male
Mice
Mice, Inbred C57BL
Ovalbumin
/ administration & dosage
Particle Size
Polylactic Acid-Polyglycolic Acid Copolymer
/ administration & dosage
Silicon Dioxide
/ administration & dosage
Controlled release
Delivery system
In situ-forming implants
PLGA
Particle release
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
24
02
2020
revised:
16
07
2020
accepted:
20
08
2020
pubmed:
30
8
2020
medline:
8
7
2021
entrez:
30
8
2020
Statut:
ppublish
Résumé
Poly (lactic-co-glycolic acid) (PLGA) in situ-forming implants are well-established drug delivery systems for controlled drug release over weeks up to months. To prevent initial burst release, which is still a major issue associated with PLGA-based implants, drugs attached to particulate carriers have been encapsulated. Unfortunately, former studies only investigated the resulting release of the soluble drugs and hence missed the potential offered by particulate drug release. In this study, we developed a system capable of releasing functional drug-carrying particles over a prolonged time. First, we evaluated the feasibility of our approach by encapsulating silica particles of different sizes (500 nm and 1 μm) and surface properties (OH or NH
Identifiants
pubmed: 32860903
pii: S0939-6411(20)30265-4
doi: 10.1016/j.ejpb.2020.08.020
pii:
doi:
Substances chimiques
Delayed-Action Preparations
0
Drug Carriers
0
Drug Implants
0
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Silicon Dioxide
7631-86-9
Ovalbumin
9006-59-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.