Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders.

Adolescent Adult Attention Deficit and Disruptive Behavior Disorders / diagnostic imaging Comorbidity Depressive Disorder, Major / epidemiology Europe Humans Irritable Mood
adolescent irritability gray matter volume inhibitory control psychopathology

Journal

Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 1527-5418
Titre abrégé: J Am Acad Child Adolesc Psychiatry
Pays: United States
ID NLM: 8704565

Informations de publication

Date de publication:
12 2020
Historique:
received: 15 10 2018
revised: 07 11 2019
accepted: 19 08 2020
pubmed: 30 8 2020
medline: 19 3 2021
entrez: 30 8 2020
Statut: ppublish

Résumé

Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries. The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses. Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume. This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.

Identifiants

DOI: 10.1016/j.jaac.2019.11.028 PMID: 32860907
pubmed: 32860907
pii: S0890-8567(20)31355-1
doi: 10.1016/j.jaac.2019.11.028
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1371-1379

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : Medical Research Council
ID : 93558
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : P20 GM103644
Pays : United States

Investigateurs

Dr Michael Rapp (DM)
Dr Eric Artiges (DE)
Sophia Schneider (S)
Christine Bach (C)
Dr Tomas Paus (DT)
Alexis Barbot (A)
Dr Gareth Barker (DG)
Dr Arun Bokde (DA)
Dr Nora Vetter (DN)
Dr Christian Büchel (DC)
Dr Anna Cattrell (DA)
Patrick Constant (P)
Penny Gowland (P)
Dr Hans Crombag (DH)
Katharina Czech (K)
Dr Jeffrey Dalley (DJ)
Benjamin Decideur (B)
Tade Spranger (T)
Dr Tamzin Ripley (DT)
Dr Nadja Heym (DN)
Herta Flor (H)
Dr Wolfgang Sommer (DW)
Birgit Fuchs (B)
Dr Jürgen Gallinat (DJ)
Dr Hugh Garavan (DH)
Dr Rainer Spanagel (DR)
Mehri Kaviani (M)
Dr Bert Heinrichs (DB)
Dr Andreas Heinz (DA)
Naresh Subramaniam (N)
Dr Tianye Jia (DT)
Albrecht Ihlenfeld (A)
James Ireland (J)
Dr Bernd Ittermann (DB)
Dr Patricia Conrod (DP)
Dr Tobias Banaschewski (DT)
Jennifer Jones (J)
Dr Arno Klaassen (DA)
Christophe Lalanne (C)
Dr Dirk Lanzerath (DD)
Dr Claire Lawrence (DC)
Dr Hervé Lemaitre (DH)
Dr Sylvane Desrivieres (DS)
Catherine Mallik (C)
Dr Karl Mann (DK)
Dr Adam Mar (DA)
Lourdes Martinez-Medina (L)
Dr Jean-Luc Martinot (DJ)
Eva Mennigen (E)
Dr Fabiana Mesquita de Carvahlo (DF)
Yannick Schwartz (Y)
Dr Ruediger Bruehl (DR)
Kathrin Müller (K)
Frauke Nees (F)
Charlotte Nymberg (C)
Dr Mark Lathrop (DM)
Dr Trevor Robbins (DT)
Dr Zdenka Pausova (DZ)
Dr Jani Pentilla (DJ)
Dr Francesca Biondo (DF)
Dr Jean-Baptiste Poline (DJ)
Dr Luise Poustka (DL)
Sabina Millenet (S)
Dr Michael Smolka (DM)
Juliane Fröhner (J)
Dr Maren Struve (DM)
Dr Steve Williams (DS)
Dr Thomas Hübner (DT)
Uli Bromberg (U)
Semiha Aydin (S)
John Rogers (J)
Alexander Romanowski (A)
Dr Christine Schmäl (DC)
Dirk Schmidt (D)
Stephan Ripke (S)
Dr Mercedes Arroyo (DM)
Dr Florian Schubert (DF)
Dr Yolanda Pena-Oliver (DY)
Mira Fauth-Bühler (M)
Xavier Mignon (X)
Dr Robert Whelan (DR)
Dr Claudia Speiser (DC)
Tahmine Fadai (T)
Dr Dai Stephens (DD)
Dr Andreas Ströhle (DA)
Dr Marie-Laure Paillere (DM)
Nicole Strache (N)
David Theobald (D)
Sarah Jurk (S)
Dr Helene Vulser (DH)
Ruben Miranda (R)
Dr Juliana Yacubilin (DJ)
Vincent Frouin (V)
Alexander Genauck (A)
Caroline Parchetka (C)
Isabel Gemmeke (I)
Johann Kruschwitz (J)
Katharina Weiss (K)
Dr Henrik Walter (DH)
Jianfeng Feng (J)
Dimitri Papadopoulos (D)
Irina Filippi (I)
Alex Ing (A)
Dr Barbara Ruggeri (DB)
Bing Xu (B)
Christine Macare (C)
Dr Congying Chu (DC)
Eanna Hanratty (E)
Dr Erin Burke Quinlan (DE)
Dr Gabriel Robert (DG)
Dr Gunter Schumann (DG)
Dr Tao Yu (DT)
Veronika Ziesch (V)
Alicia Stedman (A)

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020. Published by Elsevier Inc.

Auteurs

Bader Chaarani (B)

Vermont Center on Behavior and Health, University of Vermont, Burlington. Electronic address: Bchaarani01@gmail.com.

Kees-Jan Kan (KJ)

Vermont Center on Behavior and Health, University of Vermont, Burlington.

Scott Mackey (S)

Vermont Center on Behavior and Health, University of Vermont, Burlington.

Philip A Spechler (PA)

Vermont Center on Behavior and Health, University of Vermont, Burlington.

Alexandra Potter (A)

Vermont Center on Behavior and Health, University of Vermont, Burlington.

Tobias Banaschewski (T)

Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Sabina Millenet (S)

Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Arun L W Bokde (ALW)

Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Ireland.

Uli Bromberg (U)

University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Christian Büchel (C)

University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Anna Cattrell (A)

Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Patricia J Conrod (PJ)

Université de Montreal, CHU Ste Justine Hospital, Canada; Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Sylvane Desrivières (S)

Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Herta Flor (H)

Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; School of Social Sciences, University of Mannheim, Germany.

Vincent Frouin (V)

Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.

Jürgen Gallinat (J)

University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Penny Gowland (P)

Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.

Andreas Heinz (A)

Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

Bernd Ittermann (B)

Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.

Jean-Luc Martinot (JL)

Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn, Paris, France.

Frauke Nees (F)

Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; School of Social Sciences, University of Mannheim, Germany.

Tomáš Paus (T)

Rotman Research Institute, University of Toronto, Ontario, Canada.

Luise Poustka (L)

Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Medical University of Vienna, Austria.

Michael N Smolka (MN)

Technische Universität Dresden, Dresden, Germany.

Henrik Walter (H)

Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

Robert Whelan (R)

University College Dublin, Ireland.

Argyris Stringaris (A)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Stephen T Higgins (ST)

Vermont Center on Behavior and Health, University of Vermont, Burlington.

Gunter Schumann (G)

Université de Montreal, CHU Ste Justine Hospital, Canada.

Hugh Garavan (H)

Vermont Center on Behavior and Health, University of Vermont, Burlington.

Robert R Althoff (RR)

Vermont Center on Behavior and Health, University of Vermont, Burlington.
Université de Montreal, CHU Ste Justine Hospital, Canada.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Neural Correlates of Adolescent Irritability...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Neural Correlates of Adolescent Irritability...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Neural Correlates of Adolescent Irritability...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › Neural Correlates of Adolescent Irritability...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Neural Correlates of Adolescent Irritability...
questionsmedicales.fr › Régions géographiques › Europe › Neural Correlates of Adolescent Irritability...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neural Correlates of Adolescent Irritability...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Affect › Humeur irritable › Neural Correlates of Adolescent Irritability...