Pre-Hematopoietic Stem Cell Transplantation Lung Computed Tomography as an Alternative to the Pulmonary Function Test during the COVID-19 Pandemic.
COVID-19
Computed tomography
Pulmonary function test
Journal
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
23
06
2020
revised:
10
08
2020
accepted:
23
08
2020
pubmed:
30
8
2020
medline:
15
12
2020
entrez:
30
8
2020
Statut:
ppublish
Résumé
The pulmonary function test (PFT) is an important test for risk stratification before allogeneic transplantation (allo-HCT). However, it might be preferable to avoid PFT as much as possible in the recent era of coronavirus disease 2019 (COVID-19), because PFT requires forced expirations and might produce aerosols, increasing the risk of COVID-19 transmission. Therefore, we tried to predict normal PFT results before allo-HCT based on computed tomography (CT) findings. This study included 390 allo-HCT recipients at our center for whom lung CT images and PFT results before allo-HCT were available. Abnormal CT findings were less likely to be observed in the normal PFT group (47.0% versus 67.4%, P = .015), with a high negative predictive value of 92.9%. In a multivariate analysis, normal CT was significantly associated with normal PFT (odds ratio, 2.47; 95% confidence interval, 1.22 to 4.97; P = .012). A model for predicting normal PFT was constructed based on the results of a multivariate analysis, and the area under the curve of the receiver operating characteristic analysis was 0.656, which gave a sensitivity of 45.5% and a specificity of 86.0%. The relatively high specificity of the model suggested that PFT can be omitted in patients with normal CT findings before allo-HCT.
Identifiants
pubmed: 32860909
pii: S1083-8791(20)30540-1
doi: 10.1016/j.bbmt.2020.08.025
pmc: PMC7449931
pii:
doi:
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2318-2322Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
Références
Clin Chest Med. 2017 Dec;38(4):607-621
pubmed: 29128013
Biol Blood Marrow Transplant. 2009 Apr;15(4):490-5
pubmed: 19285637
Blood. 2010 Dec 9;116(24):5111-8
pubmed: 20826719
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Apr 12;43(4):302-307
pubmed: 32129580
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Transpl Infect Dis. 2018 Dec;20(6):e12981
pubmed: 30144374
Eur Respir J. 2018 May 3;51(5):
pubmed: 29650555
Risk Anal. 2020 May;40(5):902-907
pubmed: 32356927
Infect Dis (Lond). 2018 Apr;50(4):280-288
pubmed: 29087731
Biol Blood Marrow Transplant. 2015 Jun;21(6):1132-5
pubmed: 25748273
Bone Marrow Transplant. 2013 Mar;48(3):452-8
pubmed: 23208313
Respir Med. 2017 Aug;129:152-157
pubmed: 28732823
Am J Hematol. 2008 Mar;83(3):226-32
pubmed: 17918253
Am J Hematol. 2012 Jan;87(1):9-14
pubmed: 22031451
Radiology. 2008 Mar;246(3):697-722
pubmed: 18195376
Respir Investig. 2014 Jul;52(4):242-50
pubmed: 24998371
Am J Respir Crit Care Med. 2006 Jun 15;173(12):1309-15
pubmed: 16556695
Am Rev Respir Dis. 1970 Dec;102(6):965-9
pubmed: 5486228
Eur Radiol. 2019 Nov;29(11):6089-6099
pubmed: 31062135
Blood. 2005 Oct 15;106(8):2912-9
pubmed: 15994282
Biol Blood Marrow Transplant. 2018 Nov;24(11):2277-2284
pubmed: 29964193
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
Eur J Radiol. 2005 Sep;55(3):437-44
pubmed: 16129254