Recombinant hemagglutinin glycoproteins provide insight into binding to host cells by H5 influenza viruses in wild and domestic birds.
Animals
Animals, Domestic
/ virology
Animals, Wild
/ virology
Bursa of Fabricius
/ metabolism
Cloaca
/ metabolism
Ducks
/ virology
Eagles
/ virology
Gene Expression
Hemagglutinin Glycoproteins, Influenza Virus
/ genetics
Influenza A Virus, H5N2 Subtype
/ genetics
Influenza in Birds
/ pathology
Intestinal Mucosa
/ metabolism
Lung
/ metabolism
Poultry
/ virology
Protein Binding
Recombinant Proteins
/ genetics
Viral Tropism
/ genetics
Virulence
H5N2
Hemagglutinin
Highly pathogenic avian influenza virus
Low pathogenic avian influenza virus
Poultry
Recombinant protein
Terrestrial birds
Tropism
Waterfowl
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
25
04
2020
revised:
02
08
2020
accepted:
03
08
2020
pubmed:
30
8
2020
medline:
25
2
2021
entrez:
30
8
2020
Statut:
ppublish
Résumé
Clade 2.3.4.4, H5 subtype highly pathogenic avian influenza viruses (HPAIVs) have caused devastating effects across wild and domestic bird populations. We investigated differences in the intensity and distribution of the hemagglutinin (HA) glycoprotein binding of a clade 2.3.4.4 H5 HPAIV compared to a H5 low pathogenic avian influenza virus (LPAIV). Recombinant HA from gene sequences from a HPAIV, A/Northern pintail/Washington/40964/2014(H5N2) and a LPAIV, A/mallard/MN/410/2000(H5N2) were generated and, via protein histochemistry, HA binding in respiratory, intestinal and cloacal bursal tissue was quantified as median area of binding (MAB). Poultry species, shorebirds, ducks and terrestrial birds were used. Differences in MAB were observed between the HPAIV and LPAIV H5 HAs. We demonstrate that clade 2.3.4.4 HPAIV H5 HA has a broader host cell binding across a variety of bird species compared to the LPAIV H5 HA. These findings support published results from experimental trials, and outcomes of natural disease outbreaks with these viruses.
Identifiants
pubmed: 32861143
pii: S0042-6822(20)30148-3
doi: 10.1016/j.virol.2020.08.001
pmc: PMC7554162
mid: NIHMS1625024
pii:
doi:
Substances chimiques
Hemagglutinin Glycoproteins, Influenza Virus
0
Recombinant Proteins
0
hemagglutinin, avian influenza A virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-20Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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