Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy.

Cancer Diet Pathophysiology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
25 Sep 2020
Historique:
received: 27 12 2019
revised: 28 06 2020
accepted: 10 08 2020
medline: 30 8 2020
pubmed: 30 8 2020
entrez: 30 8 2020
Statut: epublish

Résumé

Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in GBM and assessed the role of fatty acid oxidation (FAO) in promoting GBM propagation.

Identifiants

DOI: 10.1016/j.isci.2020.101453 PMID: 32861192 PMC: PMC7471621
pubmed: 32861192
pii: S2589-0042(20)30645-3
doi: 10.1016/j.isci.2020.101453
pmc: PMC7471621
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101453

Subventions

Organisme : NCI NIH HHS
ID : P50 CA211015
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070245
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215185
Pays : United States

Informations de copyright

© 2020 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Jantzen Sperry (J)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Michael C Condro (MC)

Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA.

Lea Guo (L)

Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA.
Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

Daniel Braas (D)

UCLA Metabolomics Center, UCLA, Los Angeles, CA, USA.

Nathan Vanderveer-Harris (N)

Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA.

Kristen K O Kim (KKO)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Whitney B Pope (WB)

Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

Ajit S Divakaruni (AS)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Albert Lai (A)

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
Department of Neurology, UCLA, Los Angeles, CA, USA.

Heather Christofk (H)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
Department of Biological Chemistry, UCLA, Los Angeles, CA, USA.
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA.

Maria G Castro (MG)

Department of Neurosurgery, Department of Cell and Developmental Biology, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Pedro R Lowenstein (PR)

Department of Neurosurgery, Department of Cell and Developmental Biology, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Janel E Le Belle (JE)

Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA.

Harley I Kornblum (HI)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA.
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA.

Classifications MeSH