Watch and Wait in Mantle Cell Lymphoma.

Humans Lymphoma, Mantle-Cell / metabolism
Deferred treatment Indolent Mantle cell lymphoma Non-Hodgkin lymphoma Observation

Journal

Hematology/oncology clinics of North America
ISSN: 1558-1977
Titre abrégé: Hematol Oncol Clin North Am
Pays: United States
ID NLM: 8709473

Informations de publication

Date de publication:
10 2020
Historique:
entrez: 31 8 2020
pubmed: 31 8 2020
medline: 2 6 2021
Statut: ppublish

Résumé

Mantle cell lymphoma (MCL) is a biologically heterogeneous disease, and patients may experience a clinical course ranging from indolent to very aggressive. Observational studies suggest that a subset of patients can be safely observed for a period of months to years from initial diagnosis without adversely impacting their outcomes. However, identification of candidates for the "watch and wait" approach remains challenging because selection criteria are not well-defined. Studies that prospectively stratify patients on the basis of MCL biology and disease risk will be informative, and patients with indolent MCL may be ideal candidates for frontline clinical trials exploring novel therapies.

Identifiants

DOI: 10.1016/j.hoc.2020.06.002 PMID: 32861281
pubmed: 32861281
pii: S0889-8588(20)30065-4
doi: 10.1016/j.hoc.2020.06.002
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

837-847

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Christina Lee (C)

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, 1305 York Avenue, 7th Floor, New York, NY 10065, USA.

Peter Martin (P)

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, 1305 York Avenue, 7th Floor, New York, NY 10065, USA. Electronic address: pem9019@med.cornell.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Watch and Wait in Mantle Cell Lymphoma.
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome à cellules du manteau › Watch and Wait in Mantle Cell Lymphoma.