Percutaneous coronary intervention provided better long term results than optimal medical therapy alone in patients with chronic total occlusion: A meta-analysis.
Chronic total occlusion
Death
Myocardial infarction
Stable angina
Journal
Indian heart journal
ISSN: 2213-3763
Titre abrégé: Indian Heart J
Pays: India
ID NLM: 0374675
Informations de publication
Date de publication:
Historique:
received:
31
03
2020
revised:
21
06
2020
accepted:
07
07
2020
entrez:
31
8
2020
pubmed:
31
8
2020
medline:
1
4
2021
Statut:
ppublish
Résumé
Studies comparing the outcome of percutaneous coronary intervention (PCI) along with optimal medical therapy (OMT) versus OMT alone in treatment of chronic total occlusion (CTO) are limited by observational design, variable follow-up period, diverse clinical outcomes, high drop-out and cross-over rates. This study aims to conduct a meta-analysis of published data of observational as well as randomized studies comparing long term outcomes of PCI+OMT versus OMT alone. PubMed, Embase and Cochrane databases were systematically reviewed. 15 studies meeting criteria were included in the meta-analysis. The New-castle Ottawa scale was used to appraise the overall quality of the studies. Random-effects model with inverse variance method was undertaken. Major adverse cardiovascular events (MACE) which comprises of cardiac death, myocardial infarction, stroke, and un-planned revascularization were significantly lower in the PCI+OMT group (RR:0.76; 95% CI:0.61 to 0.95; P=<0.00001; I PCI of CTO is rewarded with better long term outcome, in terms of MACE, all-cause mortality and cardiac death with similar rates of un-planned revascularization.
Identifiants
pubmed: 32861374
pii: S0019-4832(20)30171-1
doi: 10.1016/j.ihj.2020.07.013
pmc: PMC7474112
pii:
doi:
Substances chimiques
Fibrinolytic Agents
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-231Informations de copyright
Copyright © 2020 Cardiological Society of India. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors have none to declare.
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