Diagnostic Applications of Ultrasmall Superparamagnetic Particles of Iron Oxide for Imaging Myocardial and Vascular Inflammation.
cardiac magnetic resonance
inflammation
macrophage
ultrasmall superparamagnetic particles of iron oxide
Journal
JACC. Cardiovascular imaging
ISSN: 1876-7591
Titre abrégé: JACC Cardiovasc Imaging
Pays: United States
ID NLM: 101467978
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
27
11
2019
revised:
22
05
2020
accepted:
04
06
2020
pubmed:
31
8
2020
medline:
9
10
2021
entrez:
31
8
2020
Statut:
ppublish
Résumé
Cardiac magnetic resonance (CMR) is at the forefront of noninvasive methods for the assessment of myocardial anatomy, function, and most importantly tissue characterization. The role of CMR is becoming even more significant with an increasing recognition that inflammation plays a major role for various myocardial diseases such as myocardial infarction, myocarditis, and takotsubo cardiomyopathy. Ultrasmall superparamagnetic particles of iron oxide (USPIO) are nanoparticles that are taken up by monocytes and macrophages accumulating at sites of inflammation. In this context, USPIO-enhanced CMR can provide valuable additional information regarding the cellular inflammatory component of myocardial and vascular diseases. Here, we will review the recent diagnostic applications of USPIO in terms of imaging myocardial and vascular inflammation, and highlight some of their future potential.
Identifiants
pubmed: 32861658
pii: S1936-878X(20)30633-1
doi: 10.1016/j.jcmg.2020.06.038
pii:
doi:
Substances chimiques
Ferric Compounds
0
ferric oxide
1K09F3G675
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1249-1264Subventions
Organisme : British Heart Foundation
ID : CH/09/002/26360
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/14/78/31020
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701127
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12040
Pays : United Kingdom
Informations de copyright
Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
FUNDING SUPPORT AND AUTHOR DISCLOSURES The authors have reported that they have no relationships relevant to the contents of this paper to disclose.