T2238C atrial natriuretic peptide gene variant and cardiovascular events in patients with atrial fibrillation: A substudy from the ATHERO-AF cohort.

Atrial Fibrillation / diagnosis Atrial Natriuretic Factor / genetics Cohort Studies Humans Myocardial Infarction Prospective Studies
ANP Atrial fibrillation Cardiovascular events Genetics Stroke T2238C

Journal

International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291

Informations de publication

Date de publication:
01 01 2021
Historique:
received: 30 04 2020
revised: 10 08 2020
accepted: 24 08 2020
pubmed: 31 8 2020
medline: 28 5 2021
entrez: 31 8 2020
Statut: ppublish

Résumé

The T2238C variant of the atrial natriuretic peptide (ANP) gene has emerged as a novel risk factor for the incidence of cardiovascular events. However, the impact of this variant on cardiovascular outcome in patients with atrial fibrillation (AF) is unknown. We included 557 anticoagulated patients with non-valvular AF randomly selected from the prospective ATHERO-AF cohort. Patients underwent genetic analysis for the T2238C/ANP variant and were grouped as wild type or heterozygous or homozygous for C2238 variant allele. Primary endpoint was a composite of cardiovascular events (CVEs) including cardiovascular death, fatal/non-fatal ischemic stroke and myocardial infarction. Overall, 429 patients carried the TT wild type genotype, 110 patients (19.7%) were heterozygous (T/C) and 18 patients (3.2%) were homozygous (CC). Incidence of CVEs was higher in homozygous patients for C2238 allele at unadjusted analysis (log-rank test, p = 0.042 for additive model, p = 0.043 for recessive model). The multivariable Cox proportional hazards regression analysis confirmed that C2238 ANP allele was associated with CVEs in the additive (p = 0.008) and recessive models (p = 0.005). Carrier status for the C2238/ANP variant allele is associated with an increased risk of CVEs in anticoagulated AF patients.

Sections du résumé

BACKGROUND
The T2238C variant of the atrial natriuretic peptide (ANP) gene has emerged as a novel risk factor for the incidence of cardiovascular events. However, the impact of this variant on cardiovascular outcome in patients with atrial fibrillation (AF) is unknown.
METHODS
We included 557 anticoagulated patients with non-valvular AF randomly selected from the prospective ATHERO-AF cohort. Patients underwent genetic analysis for the T2238C/ANP variant and were grouped as wild type or heterozygous or homozygous for C2238 variant allele. Primary endpoint was a composite of cardiovascular events (CVEs) including cardiovascular death, fatal/non-fatal ischemic stroke and myocardial infarction. Overall, 429 patients carried the TT wild type genotype, 110 patients (19.7%) were heterozygous (T/C) and 18 patients (3.2%) were homozygous (CC).
RESULTS
Incidence of CVEs was higher in homozygous patients for C2238 allele at unadjusted analysis (log-rank test, p = 0.042 for additive model, p = 0.043 for recessive model). The multivariable Cox proportional hazards regression analysis confirmed that C2238 ANP allele was associated with CVEs in the additive (p = 0.008) and recessive models (p = 0.005).
CONCLUSIONS
Carrier status for the C2238/ANP variant allele is associated with an increased risk of CVEs in anticoagulated AF patients.

Identifiants

DOI: 10.1016/j.ijcard.2020.08.077 PMID: 32861716
pubmed: 32861716
pii: S0167-5273(20)33704-9
doi: 10.1016/j.ijcard.2020.08.077
pii:
doi:

Substances chimiques

Atrial Natriuretic Factor 85637-73-6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

245-249

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declared they do not have anything to disclose regarding conflict of interest with respect to this manuscript.

Auteurs

Daniele Pastori (D)

Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Roberto Carnevale (R)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, Latina 40100, Italy; Mediterranea Cardiocentro, Via Orazio 2, Napoli 80122, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. Electronic address: roberto.carnevale@uniroma1.it.

Rosita Stanzione (R)

IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Cristina Nocella (C)

Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Maria Cotugno (M)

IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Simona Marchitti (S)

IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Franca Bianchi (F)

IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Maurizio Forte (M)

IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Valentina Valenti (V)

Department of Cardiology, Ospedale Santa Maria Goretti, Via Antonio Canova, Latina 04100, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Giuseppe Biondi-Zoccai (G)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, Latina 40100, Italy; Mediterranea Cardiocentro, Via Orazio 2, Napoli 80122, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Sonia Schiavon (S)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, Latina 40100, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Daniele Vecchio (D)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, Latina 40100, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Francesco Versaci (F)

Department of Cardiology, Ospedale Santa Maria Goretti, Via Antonio Canova, Latina 04100, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Giacomo Frati (G)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, Latina 40100, Italy; IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Francesco Violi (F)

Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy; Mediterranea Cardiocentro, Via Orazio 2, Napoli 80122, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Massimo Volpe (M)

IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S.Andrea, Via di Grottarossa 1035, Rome 00189, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Pasquale Pignatelli (P)

Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy; Mediterranea Cardiocentro, Via Orazio 2, Napoli 80122, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Speranza Rubattu (S)

IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Ospedale S.Andrea, Via di Grottarossa 1035, Rome 00189, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. Electronic address: rubattu.speranza@neuromed.it.

Sebastiano Sciarretta (S)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, Latina 40100, Italy; IRCCS Neuromed, Località Camerelle, Pozzilli, (IS), 86077, Italy; This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › T2238C atrial natriuretic peptide gene variant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Peptides natriurétiques › Facteur atrial natriurétique › T2238C atrial natriuretic peptide gene variant...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › T2238C atrial natriuretic peptide gene variant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › T2238C atrial natriuretic peptide gene variant...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › T2238C atrial natriuretic peptide gene variant...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › T2238C atrial natriuretic peptide gene variant...