Peripherally-sourced myeloid antigen presenting cells increase with advanced aging.
Aging
Behavior
Dendritic cells
Gut microbiota-immune-brain axis
MHC-II
Myeloid cells
Sex differences
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
25
03
2020
revised:
18
08
2020
accepted:
20
08
2020
pubmed:
31
8
2020
medline:
28
4
2021
entrez:
31
8
2020
Statut:
ppublish
Résumé
Aging is associated with dysfunction of the gut microbiota-immune-brain axis, a major regulatory axis in both brain health and in central nervous system (CNS) diseases. Antigen presenting cells (APCs) play a major role in sensing changes in the gut microbiota and regulation of innate and adaptive immune responses. APCs have also been implicated in various chronic inflammatory conditions, including age-related neurodegenerative diseases. The increase in chronic low-level inflammation seen with aging has also been linked to behavioral decline. Despite their acknowledged importance along the gut microbiota-immune-brain axis, there is limited evidence on how APCs change with aging. In this study, we examined age-related changes in myeloid APCs in the gut, spleen, and brain as well as changes in the gut microbiota and behavioral phenotype in mice ranging in age from 2 months up to 32 months of both sexes. Our data show that the number of peripherally-sourced myeloid APCs significantly increases with advanced aging in the brain. In addition, our data showed that age-related changes in APCs are subset-specific in the gut and sexually dimorphic in the spleen. Our work highlights the importance of studying myeloid APCs in an age-, tissue-, and sex-specific manner.
Identifiants
pubmed: 32861719
pii: S0889-1591(20)30405-0
doi: 10.1016/j.bbi.2020.08.023
pmc: PMC8169202
mid: NIHMS1629535
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
235-247Subventions
Organisme : NINDS NIH HHS
ID : R01 NS094543
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR003169
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103592
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058463
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS114768
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056338
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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