The multifaceted role of plasminogen in inflammation.
Animals
Blood Coagulation
COVID-19
Complement Activation
Coronavirus Infections
/ blood
Cytokine Release Syndrome
/ blood
Cytokines
/ immunology
Humans
Immune System
/ immunology
Inflammation
/ blood
Low Density Lipoprotein Receptor-Related Protein-1
/ immunology
NF-kappa B
/ immunology
Pandemics
Plasminogen
/ immunology
Pneumonia, Viral
/ blood
Tissue Plasminogen Activator
/ immunology
COVID-19
Coagulation
Complement
Cytokine
Cytokine storm syndrome
DIC
LRP1
Macrophage activation syndrome
Matrix metalloproteinase
NFkB
PAR
Plasmin
Plasminogen
Plasminogen receptor
Toll like recepotor
tPA
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
16
05
2020
revised:
24
08
2020
accepted:
24
08
2020
pubmed:
31
8
2020
medline:
21
10
2020
entrez:
31
8
2020
Statut:
ppublish
Résumé
A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted to the serine protease plasmin, a key fibrinolytic factor by plasminogen activators including tissue-type plasminogen activator (tPA). Plasmin is part of an intricate protease network controlling proteins of initial hemostasis/coagulation, fibrinolytic and complement system. Activation of these protease cascades is required to mount a proper inflammatory response. Although best known for its ability to dissolve clots and cleave fibrin, recent studies point to the importance of fibrin-independent functions of plasmin during acute inflammation and inflammation resolution. In this review, we provide an up-to-date overview of the current knowledge of the enzymatic and cytokine-like effects of tPA and describe the role of tPA and plasminogen receptors in the regulation of the inflammatory response with emphasis on the cytokine storm syndrome such as observed during coronavirus disease 2019 or macrophage activation syndrome. We discuss tPA as a modulator of Toll like receptor signaling, plasmin as an activator of NFkB signaling, and summarize recent studies on the role of plasminogen receptors as controllers of the macrophage conversion into the M2 type and as mediators of efferocytosis during inflammation resolution.
Identifiants
pubmed: 32861744
pii: S0898-6568(20)30238-2
doi: 10.1016/j.cellsig.2020.109761
pmc: PMC7452830
pii:
doi:
Substances chimiques
Cytokines
0
LRP1 protein, human
0
Low Density Lipoprotein Receptor-Related Protein-1
0
NF-kappa B
0
Plasminogen
9001-91-6
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109761Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Blood. 2008 Jun 1;111(11):5316-25
pubmed: 18369152
J Biol Chem. 1994 Aug 19;269(33):21117-22
pubmed: 8063731
Cell. 2005 Feb 11;120(3):303-13
pubmed: 15707890
J Thromb Haemost. 2017 Jan;15(1):150-154
pubmed: 27740735
J Biol Chem. 1991 Sep 5;266(25):16730-5
pubmed: 1909331
Cytokine. 2002 Dec 7;20(5):191-9
pubmed: 12550103
J Clin Invest. 1998 Jul 1;102(1):41-50
pubmed: 9649555
J Biol Chem. 2013 Nov 22;288(47):34009-34018
pubmed: 24129569
J Biol Chem. 2001 Jan 5;276(1):179-86
pubmed: 11027681
FEBS Lett. 2001 Nov 23;508(3):313-7
pubmed: 11728442
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
Blood. 2013 Jan 17;121(3):431-9
pubmed: 23086754
Nat Med. 2018 Jun;24(6):731-738
pubmed: 29808005
Nat Rev Drug Discov. 2016 Aug;15(8):551-67
pubmed: 27020098
Cell Mol Life Sci. 2015 Dec;72(24):4759-70
pubmed: 26350342
Angiogenesis. 2015 Jul;18(3):347-59
pubmed: 26026674
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
EBioMedicine. 2016 Feb 06;5:175-82
pubmed: 27077125
Genes Dev. 1995 Apr 1;9(7):794-807
pubmed: 7705657
J Biol Chem. 2011 Sep 23;286(38):33125-33
pubmed: 21795689
Cell. 1996 Nov 15;87(4):709-19
pubmed: 8929539
Front Cardiovasc Med. 2017 May 22;4:34
pubmed: 28589128
Blood. 2014 Jul 31;124(5):679-88
pubmed: 24876560
J Am Soc Nephrol. 2012 Aug;23(8):1329-38
pubmed: 22677557
J Immunol. 2001 Sep 1;167(5):2887-94
pubmed: 11509636
Semin Thromb Hemost. 2011 Jun;37(4):375-81
pubmed: 21805443
J Neurosci. 2007 Feb 21;27(8):1933-41
pubmed: 17314289
Blood. 1986 Jun;67(6):1731-7
pubmed: 3486686
Blood. 2016 Aug 25;128(8):1063-75
pubmed: 27283026
Sci Signal. 2008 Nov 25;1(47):ra15
pubmed: 19036715
J Biol Chem. 1988 Dec 5;263(34):18220-4
pubmed: 3142872
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Comput Struct Biotechnol J. 2019 Jul 02;17:917-938
pubmed: 31360331
Front Immunol. 2019 Jun 28;10:1458
pubmed: 31316511
Blood. 2017 Nov 23;130(21):2295-2306
pubmed: 28924019
Front Immunol. 2019 Aug 22;10:2011
pubmed: 31507606
Science. 2002 Jun 7;296(5574):1880-2
pubmed: 12052963
Semin Thromb Hemost. 2013 Jun;39(4):329-37
pubmed: 23532575
Semin Thromb Hemost. 2004 Feb;30(1):83-93
pubmed: 15034800
Biochemistry. 1999 Apr 6;38(14):4572-85
pubmed: 10194379
Blood. 2009 May 28;113(22):5588-98
pubmed: 19182206
Front Immunol. 2019 Mar 27;10:591
pubmed: 30972077
J Clin Invest. 1988 Dec;82(6):1948-55
pubmed: 2974046
Blood. 2017 May 25;129(21):2896-2907
pubmed: 28320709
Thromb J. 2019 Mar 29;17:4
pubmed: 30976204
Adv Drug Deliv Rev. 2016 Apr 1;99(Pt B):172-179
pubmed: 26588878
Gastroenterology. 2015 Mar;148(3):565-578.e4
pubmed: 25490065
Neural Regen Res. 2017 Mar;12(3):362-365
pubmed: 28469640
Blood. 2017 Jul 6;130(1):59-72
pubmed: 28325863
Am J Clin Pathol. 1983 Apr;79(4):405-13
pubmed: 6340459
J Immunol. 2012 Dec 15;189(12):5722-8
pubmed: 23150713
J Cell Biol. 2000 May 29;149(5):1157-66
pubmed: 10831618
J Biol Chem. 2002 Apr 26;277(17):14458-66
pubmed: 11839752
FEBS Lett. 1985 Sep 9;189(1):145-9
pubmed: 3896853
J Thromb Haemost. 2019 Dec;17(12):2174-2187
pubmed: 31393041
Nucleic Acids Res. 1991 Jun 25;19(12):3389-93
pubmed: 1905804
Sci Signal. 2009 Apr 28;2(68):ra18
pubmed: 19401592
Am J Pathol. 2007 Oct;171(4):1281-90
pubmed: 17717150
J Thromb Haemost. 2018 May 20;:
pubmed: 29779246
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1369-74
pubmed: 26787872
Leukemia. 2015 Jan;29(1):145-56
pubmed: 24791857
Thromb Res. 2010 Mar;125(3):210-5
pubmed: 20022081
Lancet Respir Med. 2020 Jul;8(7):681-686
pubmed: 32473124
BMC Cardiovasc Disord. 2015 Oct 19;15:130
pubmed: 26481314
Chest. 2003 Sep;124(3 Suppl):33S-9S
pubmed: 12970122
Curr Pharm Des. 2011;17(19):1962-9
pubmed: 21711236
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7427-31
pubmed: 1502154
Biochem Biophys Res Commun. 2006 Mar 10;341(2):299-303
pubmed: 16413499
J Immunol. 2019 Mar 1;202(5):1501-1509
pubmed: 30659107
J Endod. 1998 May;24(5):331-4
pubmed: 9641108
Arthritis Rheumatol. 2017 Jun;69(6):1135-1143
pubmed: 28217930
Blood. 2010 Feb 18;115(7):1319-30
pubmed: 19897580
J Biol Chem. 2004 Apr 2;279(14):13333-9
pubmed: 14715655
Biomed Pharmacother. 2006 Nov;60(9):561-8
pubmed: 16978830
Br J Haematol. 2005 May;129(3):307-21
pubmed: 15842654
J Leukoc Biol. 2019 Apr;105(4):729-740
pubmed: 30690783
Semin Thromb Hemost. 2000;26(6):605-18
pubmed: 11140797
Blood. 2017 Sep 14;130(11):1364-1374
pubmed: 28684538
J Biol Chem. 2006 Jan 27;281(4):2120-7
pubmed: 16303771
J Biol Chem. 2017 Nov 10;292(45):18699-18712
pubmed: 28972143
J Biol Chem. 2015 Jul 10;290(28):17262-8
pubmed: 26013822
Transplant Proc. 1993 Feb;25(1 Pt 2):1216-7
pubmed: 8442093
FEBS J. 2005 Nov;272(22):5821-31
pubmed: 16279946
FASEB J. 2017 Jun;31(6):2625-2637
pubmed: 28270519
Blood Adv. 2019 May 28;3(10):1598-1609
pubmed: 31126915
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Cell Death Dis. 2016 Nov 10;7(11):e2466
pubmed: 27831563
Nat Rev Immunol. 2008 Jul;8(7):533-44
pubmed: 18551128
FASEB J. 2019 Mar;33(3):3465-3480
pubmed: 30458112
Pharmacol Rev. 2016 Oct;68(4):1110-1142
pubmed: 27677721
Biochem Pharmacol. 2008 May 15;75(10):1974-80
pubmed: 18384756
J Biomed Biotechnol. 2012;2012:141806
pubmed: 23118495
J Neuroinflammation. 2019 Dec 6;16(1):257
pubmed: 31810478
Thromb Res. 2004;114(5-6):321-7
pubmed: 15507261
Cell Rep. 2012 Mar 29;1(3):185-90
pubmed: 22832192
Nat Med. 2018 Jun;24(6):739-748
pubmed: 29808007
Int J Lab Hematol. 2018 May;40 Suppl 1:15-20
pubmed: 29741245
J Thromb Haemost. 2020 Sep;18(9):2118-2122
pubmed: 32543119
J Immunol. 2003 Sep 1;171(5):2594-601
pubmed: 12928411
PLoS One. 2019 Nov 7;14(11):e0224738
pubmed: 31697716
Biochemistry. 1991 Feb 12;30(6):1682-91
pubmed: 1847072