The existence and function of mitochondrial component in extracellular vesicles.
Exosomes
Extracellular vesicles
Microvesicles
Mitochondrial components
Mitochondrial transfer
Journal
Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
25
05
2020
revised:
29
07
2020
accepted:
14
08
2020
pubmed:
31
8
2020
medline:
30
3
2021
entrez:
31
8
2020
Statut:
ppublish
Résumé
Intercellular transfer of mitochondria and mitochondrial components through extracellular vesicles (EVs), including microvesicles and exosomes, is an area of intense interest. The cargos that are carried by EVs define their biological activities. Mitochondria are in charge of bioenergetics and maintenance of cell viability. Increasing evidences indicate the presence of intact mitochondria or mitochondrial components in EVs, which raises many questions, how they are engulfed into EVs and what do they do? Here, we present what is currently known about the presence and function of various mitochondrial constituent in EVs. We also review current understanding about how and why mitochondrial components are encapsulated into EVs.
Identifiants
pubmed: 32861876
pii: S1567-7249(20)30174-4
doi: 10.1016/j.mito.2020.08.005
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
122-127Informations de copyright
Copyright © 2020 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.