Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery.
Journal
Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
08
05
2020
accepted:
07
08
2020
pubmed:
31
8
2020
medline:
14
9
2021
entrez:
31
8
2020
Statut:
ppublish
Résumé
Although intestinal metabolism plays an important role in drug disposition, early predictions of human outcomes are challenging, in part because of limitations of available in vitro models. To address this, we have evaluated three in vitro models of human intestine (microsomes, permeabilized enterocytes, and cryopreserved intestinal mucosal epithelium) as tools to assess intestinal metabolism and estimate the fraction escaping gut metabolism (
Identifiants
pubmed: 32862146
pii: dmd.120.000111
doi: 10.1124/dmd.120.000111
doi:
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1169-1182Informations de copyright
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.