Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis.
ACT
Extracorporeal membrane oxygenation
aPTT
anti-Xa
anticoagulation
bleeding
mortality
thromboelastometry
thrombosis
Journal
Perfusion
ISSN: 1477-111X
Titre abrégé: Perfusion
Pays: England
ID NLM: 8700166
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
pubmed:
31
8
2020
medline:
25
11
2021
entrez:
1
9
2020
Statut:
ppublish
Résumé
The purpose was to compare time-based vs anti-Xa-based anticoagulation strategies in patients on ECMO. We conducted a systematic review and meta-analysis using multiple electronic databases and included studies from inception to July 19, 2019. The proportion of bleeding, thrombosis, and mortality were evaluated.Twenty-six studies (2,086 patients) were included. Bleeding occurred in 34.2% (95%CI 25.1;43.9) of the patients with anti-Xa-based versus 41.6% (95%CI 24.9;59.4) of the patients with time-based anticoagulation strategies. Thrombosis occurred in 32.6% (95%CI 19.1;47.7) of the patients with anti-Xa-based versus 38.4% (95%CI 22.2;56.1) of the patients with time-based anticoagulation strategies. And mortality rate was 35.4% (95%CI 28.9;42.1) of the patients with anti-Xa-based versus 42.9% (95%CI 36.9;48.9) of the patients with time-based anticoagulation strategies. Among the seven studies providing results from both anticoagulation strategies, significantly fewer bleeding events occurred in the anti-Xa-based anticoagulation strategy (adjusted OR 0.49 (95%CI 0.32;0.74),
Identifiants
pubmed: 32862767
doi: 10.1177/0267659120952982
pmc: PMC8216320
doi:
Substances chimiques
Anticoagulants
0
Heparin
9005-49-6
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
501-512Commentaires et corrections
Type : CommentIn
Références
J Cardiothorac Vasc Anesth. 2020 Jan;34(1):192-207
pubmed: 31679998
Perfusion. 2017 Oct;32(7):538-546
pubmed: 28466677
Ann Am Thorac Soc. 2016 Dec;13(12):2242-2250
pubmed: 27690525
Ann Intern Med. 2013 Feb 19;158(4):280-6
pubmed: 23420236
Pediatr Crit Care Med. 2017 Nov;18(11):1055-1062
pubmed: 28922263
Lancet. 2000 Oct 7;356(9237):1228-31
pubmed: 11072941
BMJ. 2011 Jul 22;343:d4002
pubmed: 21784880
Crit Care Med. 2019 Jul;47(7):e563-e571
pubmed: 31033512
Pediatr Crit Care Med. 2015 Jan;16(1):66-74
pubmed: 25319630
Ann Intern Med. 1997 Nov 1;127(9):820-6
pubmed: 9382404
Semin Cardiothorac Vasc Anesth. 2009 Sep;13(3):154-75
pubmed: 19767408
Crit Care. 2020 Jan 20;24(1):19
pubmed: 31959232
Pediatr Crit Care Med. 2014 Jun;15(5):e198-205
pubmed: 24614609
J Crit Care. 2017 Jun;39:87-96
pubmed: 28237895
Contemp Clin Trials. 2007 Feb;28(2):105-14
pubmed: 16807131
ASAIO J. 2019 Mar/Apr;65(3):270-276
pubmed: 29746314
Minerva Anestesiol. 2016 Aug;82(8):858-66
pubmed: 27050286
Pediatr Crit Care Med. 2019 Nov;20(11):1034-1039
pubmed: 31517728
J Extra Corpor Technol. 2018 Mar;50(1):30-37
pubmed: 29559752
Anesthesiology. 2020 Mar;132(3):562-570
pubmed: 31764152
ASAIO J. 2015 May-Jun;61(3):339-44
pubmed: 25710768
ASAIO J. 2020 Mar;66(3):307-313
pubmed: 30883406
ASAIO J. 2017 Nov/Dec;63(6):793-801
pubmed: 28678046
Pediatr Crit Care Med. 2014 Feb;15(2):e72-9
pubmed: 24335992
Front Med (Lausanne). 2018 Dec 12;5:352
pubmed: 30619862
Anesth Analg. 2013 Jun;116(6):1210-22
pubmed: 23408671
ASAIO J. 2020 Mar;66(3):300-306
pubmed: 31045921
ASAIO J. 2014 Jan-Feb;60(1):57-62
pubmed: 24296776
Perfusion. 2017 Nov;32(8):675-685
pubmed: 28693359
Expert Rev Respir Med. 2012 Aug;6(4):377-84
pubmed: 22971063
ASAIO J. 2021 Feb 1;67(2):196-200
pubmed: 33512915
Perfusion. 2014 Sep;29(5):456-61
pubmed: 24570077
Thromb Res. 2019 Jul;179:132-139
pubmed: 31132667
Nurs Res. 2003 Jul-Aug;52(4):256-61
pubmed: 12867783
ASAIO J. 2013 Jan-Feb;59(1):63-8
pubmed: 23263338
Am J Respir Crit Care Med. 2017 Sep 15;196(6):762-771
pubmed: 28328243
J Extra Corpor Technol. 2018 Sep;50(3):149-154
pubmed: 30250340
Pediatr Crit Care Med. 2014 May;15(4):e175-82
pubmed: 24622165
Arch Surg. 2000 Sep;135(9):1042-7
pubmed: 10982508
Am J Cardiovasc Drugs. 2017 Dec;17(6):425-439
pubmed: 28536932
BMJ. 2009 Jul 21;339:b2535
pubmed: 19622551
Pediatr Crit Care Med. 2013 Feb;14(2):e77-84
pubmed: 23287906
J Epidemiol Community Health. 2013 Nov 1;67(11):974-8
pubmed: 23963506