Seasonal Variations in the Incidence of Ischemic Stroke, Extracranial and Intracranial Hemorrhage in Atrial Fibrillation Patients.
Administration, Oral
Aged
Anticoagulants
/ adverse effects
Atrial Fibrillation
/ drug therapy
Brain Ischemia
/ epidemiology
Comorbidity
Female
Follow-Up Studies
Humans
Incidence
Intracranial Hemorrhages
/ chemically induced
Ischemic Stroke
/ epidemiology
Male
Middle Aged
Retrospective Studies
Risk Factors
Seasons
Tokyo
/ epidemiology
Treatment Outcome
Warfarin
/ adverse effects
Atrial fibrillation
Hemorrhage
Ischemic stroke
Seasonal variation
Journal
Circulation journal : official journal of the Japanese Circulation Society
ISSN: 1347-4820
Titre abrégé: Circ J
Pays: Japan
ID NLM: 101137683
Informations de publication
Date de publication:
25 09 2020
25 09 2020
Historique:
pubmed:
31
8
2020
medline:
14
10
2021
entrez:
1
9
2020
Statut:
ppublish
Résumé
Ischemic stroke (IS) and major bleeding, which are serious adverse events in patients with atrial fibrillation (AF), could have seasonal variations, but there are few reports.Methods and Results:In the Shinken Database 2004-2016 (n=22,018), 3,581 AF patients (average age, 63.5 years; 2,656 men, 74.2%; 1,388 persistent AF, 38.8%) were identified. Median CHADS Significant seasonal variations were observed for IS, ECH, and ICH events in AF patients, and were consistently the highest in winter. A small peak of ECH was observed in summer, which seemed, in part, to be related to increased DOAC use.
Sections du résumé
BACKGROUND
Ischemic stroke (IS) and major bleeding, which are serious adverse events in patients with atrial fibrillation (AF), could have seasonal variations, but there are few reports.Methods and Results:In the Shinken Database 2004-2016 (n=22,018), 3,581 AF patients (average age, 63.5 years; 2,656 men, 74.2%; 1,388 persistent AF, 38.8%) were identified. Median CHADS
CONCLUSIONS
Significant seasonal variations were observed for IS, ECH, and ICH events in AF patients, and were consistently the highest in winter. A small peak of ECH was observed in summer, which seemed, in part, to be related to increased DOAC use.
Identifiants
pubmed: 32863288
doi: 10.1253/circj.CJ-20-0134
doi:
Substances chimiques
Anticoagulants
0
Warfarin
5Q7ZVV76EI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM