Eukaryotic translation initiation factor 5A in the pathogenesis of cancers.
apoptosis
cancer
eukaryotic translation initiation factor 5A
metastasis
proliferation
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
12
03
2020
accepted:
10
06
2020
entrez:
1
9
2020
pubmed:
31
8
2020
medline:
31
8
2020
Statut:
ppublish
Résumé
Cancer is the leading cause of death worldwide. The absence of obvious symptoms and insufficiently sensitive biomarkers in early stages of carcinoma limits early diagnosis. Cancer therapy agents and targeted therapy have been used extensively against tissues or organs of specific cancers. However, the intrinsic and/or acquired resistance to the agents or targeted drugs as well as the serious toxic side effects of the drugs would limit their use. Therefore, identifying biomarkers involved in tumorigenesis and progression represents a challenge for cancer diagnosis and therapeutic strategy development. The eukaryotic translation factor 5A (eIF5A), originally identified as an initiation factor, was later shown to promote translation elongation of iterated proline sequences. There are two eIF5A isoforms (eIF5A1 and eIF5A2). eIF5A2 protein consists of 153 residues, and shares 84% amino acid identity with eIF5A1. However, the biological functions of these two isoforms may be significantly different. Recently, it was demonstrated that eIF5Ais widely involved in the pathogenesis of a number of diseases, including cancers. In particular, eIF5A plays an important role in regulating tumor growth, invasion, metastasis and tumor microenvironment. It was also shown to serve as a potential biomarker and target for the diagnosis and treatment of cancers. The present review briefly discusses the latest findings of eIF5A in the pathogenesis of certain malignant cancers and evolving clinical applications.
Identifiants
pubmed: 32863914
doi: 10.3892/ol.2020.11942
pii: OL-0-0-11942
pmc: PMC7436936
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
81Informations de copyright
Copyright: © Ning et al.
Références
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):51-6
pubmed: 16371467
Oncotarget. 2015 Sep 22;6(28):26079-89
pubmed: 26317793
Int J Biol Sci. 2018 Nov 13;14(14):2083-2093
pubmed: 30585271
Am J Transl Res. 2018 Dec 15;10(12):4269-4279
pubmed: 30662669
Cancer Res. 2018 Mar 15;78(6):1444-1456
pubmed: 29321164
Am J Transl Res. 2017 Feb 15;9(2):478-488
pubmed: 28337276
Methods Mol Biol. 2019;1983:151-171
pubmed: 31087297
Cancer Cell Int. 2020 Apr 29;20:142
pubmed: 32368188
Jpn J Clin Oncol. 2018 Mar 1;48(3):214-241
pubmed: 29378002
Adv Exp Med Biol. 2017;1018:11-21
pubmed: 29052129
J Cancer Res Clin Oncol. 2013 Apr;139(4):691-702
pubmed: 23322277
Cancer Res. 2004 Jun 15;64(12):4197-200
pubmed: 15205331
Int J Cancer. 2011 Jul 1;129(1):143-50
pubmed: 20830705
Clin Cancer Res. 2017 Jan 1;23(1):124-136
pubmed: 27358487
Br J Cancer. 2014 Jan 21;110(2):399-408
pubmed: 24178756
Neoplasia. 2018 Jul;20(7):745-756
pubmed: 29925042
Int J Hepatol. 2012;2012:760928
pubmed: 23029619
Updates Surg. 2018 Jun;70(2):157-159
pubmed: 29869781
Prostate Cancer Prostatic Dis. 2019 Mar;22(1):24-38
pubmed: 30131604
World J Oncol. 2019 Feb;10(1):10-27
pubmed: 30834048
Oncol Lett. 2018 Sep;16(3):3642-3650
pubmed: 30127973
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
JAMA. 2019 Aug 27;322(8):764-774
pubmed: 31454018
World J Gastroenterol. 2015 Aug 21;21(31):9337-47
pubmed: 26309359
Cancer Sci. 2009 May;100(5):896-902
pubmed: 19298601
Eur J Cell Biol. 2012 Nov-Dec;91(11-12):902-7
pubmed: 22658792
Funct Integr Genomics. 2013 Jun;13(2):253-60
pubmed: 23539416
Biomaterials. 2016 Mar;81:125-134
pubmed: 26731576
Breast Cancer. 2015 Nov;22(6):602-7
pubmed: 24638963
Lancet. 2014 Dec 6;384(9959):2027-35
pubmed: 25108889
Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):413-25
pubmed: 25029904
Adv Exp Med Biol. 2018;1072:171-175
pubmed: 30178341
Biomed Res Int. 2018 Aug 5;2018:1769040
pubmed: 30175116
J Ethnopharmacol. 2010 Feb 17;127(3):652-61
pubmed: 19995598
Adv Exp Med Biol. 2019;1152:51-64
pubmed: 31456179
Gut. 2012 Apr;61(4):562-75
pubmed: 21813470
Nat Genet. 2014 Sep;46(9):1001-1006
pubmed: 25129146
Cell Metab. 2019 Aug 6;30(2):352-363.e8
pubmed: 31130465
Br J Nurs. 2018 Oct 4;27(18):S8-S20
pubmed: 30281356
J Clin Invest. 2010 Jun;120(6):2156-70
pubmed: 20501948
Brain Tumor Pathol. 2019 Apr;36(2):29-39
pubmed: 30859343
Hum Pathol. 2008 Jan;39(1):80-6
pubmed: 17949776
PLoS One. 2012;7(8):e43468
pubmed: 22927971
Expert Rev Anticancer Ther. 2017 Apr;17(4):369-386
pubmed: 28142287
Exp Ther Med. 2019 May;17(5):3741-3747
pubmed: 30988760
Int J Gynecol Cancer. 2019 Mar;29(3):474-479
pubmed: 30833436
Nat Rev Urol. 2019 Jul;16(7):433-445
pubmed: 31015643
Cell. 2010 Apr 2;141(1):52-67
pubmed: 20371345
Biochemistry (Mosc). 2018 Aug;83(8):863-873
pubmed: 30208826
Eur J Pharmacol. 2017 Feb 15;797:1-8
pubmed: 28088387
Clin Cancer Res. 2019 Nov 15;25(22):6721-6730
pubmed: 31515456
Scand J Urol. 2017 Apr;51(2):87-94
pubmed: 28535714
CA Cancer J Clin. 2018 Jan;68(1):7-30
pubmed: 29313949
Eur Urol Oncol. 2019 Feb;2(1):47-76
pubmed: 30929846
Oncol Res. 2020 Sep 1;28(4):345-355
pubmed: 32138807
Int J Biol Sci. 2020 Jan 16;16(5):827-837
pubmed: 32071552
Sci Rep. 2016 Jul 04;6:28301
pubmed: 27376958
Nat Rev Dis Primers. 2016 Aug 25;2:16061
pubmed: 27558151
Carcinogenesis. 2017 Jan;38(1):94-104
pubmed: 27879277
Oncotarget. 2014 Aug 30;5(16):6716-33
pubmed: 25071013
Ann Intern Med. 2015 Dec 15;163(12):922-31
pubmed: 26501851
Nat Rev Cancer. 2019 Jan;19(1):9-31
pubmed: 30532012
Lancet. 2007 Sep 8;370(9590):890-907
pubmed: 17826171
Br J Cancer. 2000 May;82(9):1535-8
pubmed: 10789720
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
pubmed: 21296855
Tumour Biol. 2016 Jan;37(1):1189-95
pubmed: 26282002
Cancers (Basel). 2017 Nov 16;9(11):
pubmed: 29144412
Biomed Pharmacother. 2018 Jan;97:473-480
pubmed: 29091897
Int Rev Psychiatry. 2014 Feb;26(1):4-15
pubmed: 24716497
J Cell Mol Med. 2019 Nov;23(11):7190-7199
pubmed: 30801960
Curr Med Chem. 2017;24(28):3012-3024
pubmed: 28494747
Tohoku J Exp Med. 2014;232(4):269-76
pubmed: 24695215
Biochem J. 2018 Jan 31;475(2):531-545
pubmed: 29295892
J Biol Chem. 2012 Oct 12;287(42):35251-9
pubmed: 22908221
Biochem Biophys Res Commun. 2018 Sep 26;504(1):6-12
pubmed: 30170728
Eur Rev Med Pharmacol Sci. 2016 Apr;20(7):1244-50
pubmed: 27097942
Target Oncol. 2019 Feb;14(1):15-32
pubmed: 30694442
Cancer Sci. 2014 Feb;105(2):219-27
pubmed: 24262005
PLoS One. 2015 Mar 20;10(3):e0119229
pubmed: 25793713
Gut. 2012 Apr;61(4):473-4
pubmed: 22180060
Cancer Res. 2017 Apr 15;77(8):1997-2007
pubmed: 28381547
Cell Cycle. 2020 Apr;19(7):742-757
pubmed: 32089066
Am J Transl Res. 2016 Nov 15;8(11):4670-4681
pubmed: 27904670
PLoS One. 2013 Aug 22;8(8):e71988
pubmed: 23991020
Lancet. 2009 Jul 18;374(9685):239-49
pubmed: 19520422
Clin Cancer Res. 2015 Jul 15;21(14):3286-97
pubmed: 25878333
Hepatology. 2010 Apr;51(4):1255-63
pubmed: 20112425
Int J Biochem Cell Biol. 2019 Feb;107:104-115
pubmed: 30578954
Oncotarget. 2016 Apr 26;7(17):24348-60
pubmed: 27028999
Mol Cancer. 2013 May 02;12:35
pubmed: 23638878
JAMA. 2013 Nov 6;310(17):1842-50
pubmed: 24193082
Neoplasma. 2019 Mar 5;66(2):176-186
pubmed: 30509106
Technol Cancer Res Treat. 2017 Oct;16(5):630-638
pubmed: 27609633
J Immunol Res. 2017;2017:1073947
pubmed: 28642882
Biol Pharm Bull. 2016;39(10):1739-1742
pubmed: 27725455
Oncologist. 2008 Mar;13(3):299-305
pubmed: 18378540
Stem Cells. 2018 Feb;36(2):180-191
pubmed: 29119708
Clin Chem. 2013 Jan;59(1):85-93
pubmed: 23193058
Br J Cancer. 2014 Apr 2;110(7):1767-77
pubmed: 24504366
Gastroenterology. 2014 Jun;146(7):1701-13.e9
pubmed: 24561231
Methods Mol Biol. 2015;1238:405-24
pubmed: 25421673
Adv Exp Med Biol. 2018;1060:99-114
pubmed: 30155624
Biochim Biophys Acta. 2015 Jul;1849(7):836-44
pubmed: 25979826
Cancer Res. 2006 Jan 15;66(2):1181-90
pubmed: 16424057
Future Oncol. 2019 Jun;15(17):2009-2018
pubmed: 30931608
Lancet. 2013 Feb 2;381(9864):400-12
pubmed: 23374478
Eur Urol. 2012 Nov;62(5):745-52
pubmed: 22704366
Mol Cell Proteomics. 2019 Oct;18(10):2029-2043
pubmed: 31353322
Curr Pharm Des. 2013;19(40):7126-40
pubmed: 23829373
Mol Cell. 2019 Oct 3;76(1):110-125.e9
pubmed: 31474573
Neuro Oncol. 2019 Jan 1;21(1):59-70
pubmed: 30053126
Obstet Gynecol. 2009 Apr;113(4):775-82
pubmed: 19305319
EMBO Rep. 2018 Jun;19(6):
pubmed: 29712776
Cell Oncol (Dordr). 2014 Dec;37(6):387-98
pubmed: 25315710
BMC Pulm Med. 2014 Nov 07;14:174
pubmed: 25380840
Amino Acids. 2013 Jan;44(1):103-9
pubmed: 22139412
Proteomics. 2003 Apr;3(4):496-504
pubmed: 12687616
Gynecol Oncol. 2009 Feb;112(2):314-8
pubmed: 19054548
J Cell Mol Med. 2019 Apr;23(4):2678-2688
pubmed: 30761741
Neuro Oncol. 2012 Nov;14 Suppl 5:v1-49
pubmed: 23095881
Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15635-15644
pubmed: 31300537
Cancer Cell. 2018 Oct 8;34(4):536-548
pubmed: 30146333
Cancer Res. 2014 Jan 15;74(2):552-62
pubmed: 24220243
Oncol Lett. 2018 Jan;15(1):813-820
pubmed: 29399149
Cancer Res. 2016 Dec 15;76(24):7219-7230
pubmed: 27569208
Pancreatology. 2019 Jul;19(5):672-680
pubmed: 31285145
ESMO Open. 2019 Feb 7;3(Suppl 1):e000462
pubmed: 30997156
Lancet. 2017 Jan 21;389(10066):299-311
pubmed: 27574741
J Appl Genet. 2019 Nov;60(3-4):335-346
pubmed: 31372832
Dig Dis Sci. 2014 Oct;59(10):2477-87
pubmed: 24811246
Int J Cancer. 2010 Aug 15;127(4):968-76
pubmed: 19998337
Dis Model Mech. 2014 Aug;7(8):963-76
pubmed: 24832488
N Engl J Med. 2010 Sep 30;363(14):1324-34
pubmed: 20879881
J Biol Chem. 2018 Nov 30;293(48):18710-18718
pubmed: 30257869
Genomics. 2001 Jan 1;71(1):101-9
pubmed: 11161802
N Engl J Med. 2011 Sep 22;365(12):1118-27
pubmed: 21992124
Exp Ther Med. 2017 Sep;14(3):2101-2107
pubmed: 28962130
J Biol Chem. 2009 Sep 11;284(37):24696-704
pubmed: 19584056
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787
Int J Clin Oncol. 2019 Jul;24(7):771-778
pubmed: 30980196
Jpn J Surg. 1986 Sep;16(5):305-10
pubmed: 3467109
Adv Drug Deliv Rev. 2017 May 15;114:206-221
pubmed: 28449873
Cancer Lett. 2009 Aug 8;280(2):222-32
pubmed: 19268440
Lab Chip. 2018 Dec 18;19(1):11-34
pubmed: 30480287
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Breast Dis. 2006-2007;26:157-62
pubmed: 17473374
Cancer Lett. 2017 Feb 28;387:61-68
pubmed: 26845449
Mediators Inflamm. 2016;2016:6058147
pubmed: 26966341
Biomed Pharmacother. 2018 Apr;100:168-175
pubmed: 29428664
J Zhejiang Univ Sci B. 2013 Jun;14(6):460-7
pubmed: 23733422
Exp Cell Res. 2013 Oct 15;319(17):2708-17
pubmed: 23958463
Cancer Manag Res. 2018 Dec 14;10:6997-7011
pubmed: 30588104
Pediatr Blood Cancer. 2013 Jun;60(6):985-93
pubmed: 23255319
Cancer Res. 2016 Sep 15;76(18):5467-78
pubmed: 27503926
CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29
pubmed: 24399786
Gene. 2018 Jan 30;641:105-110
pubmed: 29017963
Clin Exp Pharmacol Physiol. 2016 Aug;43(8):723-37
pubmed: 27097837
CNS Neurosci Ther. 2020 Jan;26(1):66-75
pubmed: 31102349
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009
Blood. 2007 Feb 15;109(4):1701-11
pubmed: 17008552
Histopathology. 2016 Aug;69(2):276-87
pubmed: 26799253