Downregulation of ZNF365 by methylation predicts poor prognosis in patients with colorectal cancer by decreasing phospho-p53 (Ser15) expression.
DNA methylation
ZNF365
colorectal cancer
immunohistochemistry
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
08
08
2019
accepted:
26
06
2020
entrez:
1
9
2020
pubmed:
31
8
2020
medline:
31
8
2020
Statut:
ppublish
Résumé
ZNF365 is a transcription factor that plays important roles in different types of cancer, such as colorectal cancer, breast cancer and hepatocellular carcinoma. ZNF365 can promote stalled replication fork recovery to prevent genomic instability, which is a notable feature of sporadic and hereditary types of cancers. However, the function of ZNF365 in the tumor progression of colorectal cancer (CRC) remains unclear. Thus, immunohistochemical staining was used to investigate the association between ZNF365 expression and the clinicopathological characteristics of patients with colorectal cancer. The results demonstrated that ZNF365 protein was strongly expressed in the nucleus and cytoplasm of normal colorectal mucosa. Furthermore ZNF365, which is methylated and downregulated in most cancer cell lines and tissues, was significantly associated with lymph node metastasis (P=0.015), depth of invasion (P=0.031) and histopathological grading (P=0.042). A positive correlation was observed between ZNF365 expression and phosphorylated (P)-p53 (Ser15) protein expression (r=0.18; P=0.038). Survival analysis indicated that patients with high ZNF365 expression had a higher survival rate than those with low ZNF365 expression (P=0.009), suggesting that ZNF365 may be an independent prognostic factor for survival in colorectal cancer (P=0.046). Taken together, the results of the present study demonstrated that ZNF365 was frequently inactivated by promoter methylation and independently predicted poor prognosis in patients with colorectal cancer by downregulating P-p53 (Ser15) expression.
Identifiants
pubmed: 32863918
doi: 10.3892/ol.2020.11946
pii: OL-0-0-11946
pmc: PMC7436887
doi:
Types de publication
Journal Article
Langues
eng
Pagination
85Informations de copyright
Copyright: © Wang et al.
Références
Cancer Res. 2011 Mar 15;71(6):2276-85
pubmed: 21278235
DNA Res. 1998 Dec 31;5(6):355-64
pubmed: 10048485
Nat Rev Cancer. 2006 Feb;6(2):107-16
pubmed: 16491070
Aliment Pharmacol Ther. 2010 Jun;31(11):1186-91
pubmed: 20222910
Exp Cell Res. 2007 Jan 15;313(2):254-63
pubmed: 17137575
Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8
pubmed: 20177397
Urolithiasis. 2014 Oct;42(5):395-400
pubmed: 25060549
Mutagenesis. 2012 Mar;27(2):211-8
pubmed: 22294769
Int J Cancer. 2015 Feb 15;136(4):844-53
pubmed: 24948044
Neuropsychopharmacology. 2013 Jan;38(1):23-38
pubmed: 22781841
Cell. 1997 Oct 31;91(3):325-34
pubmed: 9363941
Int J Mol Sci. 2019 Nov 28;20(23):
pubmed: 31795192
Nat Rev Cancer. 2001 Dec;1(3):233-40
pubmed: 11902578
Oncogene. 2006 Feb 16;25(7):1070-80
pubmed: 16247458
Cancer Res. 2008 Jun 1;68(11):4321-30
pubmed: 18519692
Crit Rev Eukaryot Gene Expr. 2007;17(4):295-316
pubmed: 17725495
Br J Ophthalmol. 2016 Mar;100(3):436-42
pubmed: 26628628
Cancer. 2000 Jun 15;88(12):2887
pubmed: 10870076
Hum Mol Genet. 2002 Sep 1;11(18):2091-102
pubmed: 12189161
Gut. 2011 Aug;60(8):1060-7
pubmed: 21257989
Cancer Res. 1986 Feb;46(2):461-6
pubmed: 2416425
Biochem Biophys Res Commun. 2007 Nov 30;363(4):895-900
pubmed: 17910948
Nat Genet. 2012 Nov;44(11):1222-6
pubmed: 23042114
Nucleic Acids Res. 2003 Jan 15;31(2):532-50
pubmed: 12527760
J Gastrointest Cancer. 2020 Jun 6;:
pubmed: 32506290
Nat Clin Pract Oncol. 2005 Dec;2 Suppl 1:S4-11
pubmed: 16341240
Tumour Biol. 2014 Jul;35(7):6195-206
pubmed: 25051912
Oncogene. 2005 Apr 18;24(17):2899-908
pubmed: 15838523
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W214-20
pubmed: 20576703
Nature. 1992 Jul 2;358(6381):15-6
pubmed: 1614522
Cancer Res. 2000 Dec 15;60(24):6788-93
pubmed: 11156366
Nat Genet. 2011 Mar;43(3):185-7
pubmed: 21278746
Cancer Discov. 2013 Jul;3(7):798-811
pubmed: 23776040
Ann Surg Oncol. 2010 Jun;17(6):1471-4
pubmed: 20180029
Adv Cancer Res. 1983;40:1-30
pubmed: 6197868
Cell Cycle. 2013 Sep 1;12(17):2817-28
pubmed: 23966166
Cancer Res. 2011 Oct 15;71(20):6524-34
pubmed: 21852383
Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):645-57
pubmed: 22351618
Am J Hum Genet. 2003 Jun;72(6):1479-91
pubmed: 12740763
Curr Opin Struct Biol. 2001 Feb;11(1):39-46
pubmed: 11179890