Effects of intraperitoneal injection of magnetic graphene oxide on the improvement of acute liver injury induced by CCl
Liver
Magnetic graphene oxide
Nanomaterial
Journal
Biomaterials research
ISSN: 1226-4601
Titre abrégé: Biomater Res
Pays: England
ID NLM: 101650636
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
02
2020
accepted:
22
07
2020
entrez:
1
9
2020
pubmed:
31
8
2020
medline:
31
8
2020
Statut:
epublish
Résumé
Liver failure is usually associated with the inflammation and oxidation of hepatocytes. Due to their unique properties, graphene and graphene-based nanostructures such as magnetic graphene oxide (MGO) are useful in biomedicine and engineering. In this study, synthesized MGO was used to improve the liver failure induced by carbon tetrachloride (CCl In order to provide a rat model of acute liver failure, male rats were intraperitoneally injected with 2 ml/kg body weight CCl The results indicated that the MGO injection reduced all CCl The hepatoprotective effects of MGO might be due to histopathological suppression and inflammation inhibition in the liver.
Sections du résumé
BACKGROUND
BACKGROUND
Liver failure is usually associated with the inflammation and oxidation of hepatocytes. Due to their unique properties, graphene and graphene-based nanostructures such as magnetic graphene oxide (MGO) are useful in biomedicine and engineering. In this study, synthesized MGO was used to improve the liver failure induced by carbon tetrachloride (CCl
MATERIALS AND METHODS
METHODS
In order to provide a rat model of acute liver failure, male rats were intraperitoneally injected with 2 ml/kg body weight CCl
RESULTS
RESULTS
The results indicated that the MGO injection reduced all CCl
CONCLUSION
CONCLUSIONS
The hepatoprotective effects of MGO might be due to histopathological suppression and inflammation inhibition in the liver.
Identifiants
pubmed: 32864158
doi: 10.1186/s40824-020-00192-5
pii: 192
pmc: PMC7449094
doi:
Types de publication
Journal Article
Langues
eng
Pagination
14Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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