Determination of the phenotypic age in residents of Mexico City: effect of accelerated ageing on lung function and structure.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
21
02
2020
accepted:
30
04
2020
entrez:
1
9
2020
pubmed:
31
8
2020
medline:
31
8
2020
Statut:
epublish
Résumé
Phenotypic age better represents age-related biological dysregulation than chronological age. Recently, a multisystem-based ageing measure, which integrates chronological age and nine biomarkers, was proposed. Phenotypic age was determined in 774 residents of Mexico City over 60 years old and without respiratory problems. We arbitrarily classified as "accelerated" ageing, those showing >4 years compared with their chronological age, and "slowed" ageing, those with <4 years compared with chronological age. Demographic risk factors were analysed with structured questionnaires. Lung structure was evaluated by high-resolution computed tomography and functional competence was analysed by forced vital capacity (FVC), forced expiratory volume in 1 s (FEV Overall, 13% of this cohort showed accelerated ageing, which was corroborated with four independent biomarkers of ageing, 42% had normal ageing and 46% had slowed ageing. Risk factors associated with accelerated ageing were male sex (OR 4.4, 95% CI 2.4-7.9; p<0.01), diabetes mellitus (OR 9.7, 95% CI 5.5-17.2; p<0.01), and long-term sleep duration (OR 2.9 95% CI 1.34-6.35, p<0.01). Among smokers, there was a slight but significant association with the number of pack-years. Subjects with accelerated ageing showed decreased FVC (p<0.0001), FEV A small but significant proportion of residents of Mexico City age rapidly, which is associated with male sex, diabetes, and long-term sleep duration. They exhibit lower levels of lung function and develop emphysema more frequently.
Identifiants
pubmed: 32864379
doi: 10.1183/23120541.00084-2020
pii: 00084-2020
pmc: PMC7445116
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: I. Buendia-Roldan has nothing to disclose. Conflict of interest: R. Fernández-Plata has nothing to disclose. Conflict of interest: A. Valdes-Bartolo has nothing to disclose. Conflict of interest: M. Mejia has nothing to disclose. Conflict of interest: L.E. Jaramillo has nothing to disclose. Conflict of interest: D. Martinez-Briseño has nothing to disclose. Conflict of interest: A. Santiago-Ruiz has nothing to disclose. Conflict of interest: H. Tapia-Aguilar has nothing to disclose. Conflict of interest: B. Gómez-Zamora has nothing to disclose. Conflict of interest: A. Pardo has nothing to disclose. Conflict of interest: M. Selman has nothing to disclose.
Références
Proc Am Thorac Soc. 2009 Dec 1;6(7):570-2
pubmed: 19934351
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
Clin Radiol. 1982 Jul;33(4):379-87
pubmed: 7083738
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
J Pathol. 2020 Apr;250(5):624-635
pubmed: 31691283
Eur Respir J. 2004 Jun;23(6):932-46
pubmed: 15219010
Aging Cell. 2017 Aug;16(4):624-633
pubmed: 28544158
PLoS Med. 2019 Feb 25;16(2):e1002760
pubmed: 30802240
Eur Heart J. 2011 Jun;32(12):1484-92
pubmed: 21300732
Radiology. 2009 May;251(2):566-73
pubmed: 19401580
Aging (Albany NY). 2020 Jan 11;12(1):518-542
pubmed: 31926111
Am J Epidemiol. 2018 Jun 1;187(6):1220-1230
pubmed: 29149257
PLoS Med. 2019 Jun 18;16(6):e1002827
pubmed: 31211779
PLoS Med. 2018 Dec 31;15(12):e1002718
pubmed: 30596641
Curr Drug Metab. 2018;19(12):979-985
pubmed: 29956620
Clin Interv Aging. 2018 Sep 10;13:1649-1656
pubmed: 30237701
Am J Respir Crit Care Med. 2015 Feb 1;191(3):261-9
pubmed: 25590812
Eur Respir J. 1999 Jan;13(1):197-205
pubmed: 10836348
J Appl Physiol (1985). 1994 Oct;77(4):1875-84
pubmed: 7836212
J Bras Pneumol. 2012 Jul-Aug;38(4):494-502
pubmed: 22964934
Diabetes Care. 2008 Oct;31(10):1991-6
pubmed: 18628569
Qual Life Res. 2011 Dec;20(10):1727-36
pubmed: 21479777
J Gerontol A Biol Sci Med Sci. 2012 Mar;67(3):264-75
pubmed: 22138206
Radiology. 2000 Mar;214(3):831-6
pubmed: 10715053
Exp Gerontol. 2015 Oct;70:18-25
pubmed: 26255046
Eur Respir J. 2017 Sep 11;50(3):
pubmed: 28893869
BMC Cancer. 2018 Nov 21;18(1):1149
pubmed: 30463535
Radiology. 2008 Mar;246(3):697-722
pubmed: 18195376
Lancet. 2005 Nov 26;366(9500):1875-81
pubmed: 16310554
N Engl J Med. 2011 Mar 10;364(10):897-906
pubmed: 21388308
Genome Biol. 2019 Nov 25;20(1):249
pubmed: 31767039
J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74
pubmed: 23213031
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Sci Rep. 2018 Mar 26;8(1):5210
pubmed: 29581467
Aging (Albany NY). 2019 Apr 14;11(7):2045-2070
pubmed: 31009935