International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium.
Databases
Outcomes research
Viral infection
Journal
NPJ digital medicine
ISSN: 2398-6352
Titre abrégé: NPJ Digit Med
Pays: England
ID NLM: 101731738
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
04
2020
accepted:
16
06
2020
entrez:
1
9
2020
pubmed:
31
8
2020
medline:
31
8
2020
Statut:
epublish
Résumé
We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.
Identifiants
pubmed: 32864472
doi: 10.1038/s41746-020-00308-0
pii: 308
pmc: PMC7438496
doi:
Types de publication
Journal Article
Langues
eng
Pagination
109Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL148394
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM013345
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsR.B. and A.M. are shareholders of Biomeris s.r.l.
Références
Methods Inf Med. 2018 Jul;57(S 01):e50-e56
pubmed: 30016818
Genet Med. 2020 Feb;22(2):371-380
pubmed: 31481752
AMIA Annu Symp Proc. 2012;2012:228-36
pubmed: 23304292
JAMA. 2020 Mar 23;:
pubmed: 32203977
Nat Rev Rheumatol. 2020 Jun;16(6):293-294
pubmed: 32242121
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D267-70
pubmed: 14681409
Lab Med. 2015 Spring;46(2):168-74
pubmed: 25918199
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):578-82
pubmed: 24821743
J Am Med Inform Assoc. 2009 Sep-Oct;16(5):624-30
pubmed: 19567788
J Am Med Inform Assoc. 2012 Mar-Apr;19(2):181-5
pubmed: 22081225
J Am Med Inform Assoc. 2010 Mar-Apr;17(2):124-30
pubmed: 20190053
Bioinformatics. 2018 Apr 15;34(8):1431-1432
pubmed: 29267850
Yearb Med Inform. 2018 Aug;27(1):129-139
pubmed: 30157516
AMIA Annu Symp Proc. 2013 Nov 16;2013:1525-32
pubmed: 24551424
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):615-20
pubmed: 24821734
JAMA Cardiol. 2020 Mar 27;:
pubmed: 32219362
Emerg Infect Dis. 2020 Jul;26(7):1618-1620
pubmed: 32197060
JAMIA Open. 2018 Oct;1(2):147-152
pubmed: 30474072
Clin Transl Sci. 2017 Sep;10(5):311-313
pubmed: 28271602
Lancet Gastroenterol Hepatol. 2020 May;5(5):428-430
pubmed: 32145190
Clin Chem Lab Med. 2020 Jun 25;58(7):1131-1134
pubmed: 32119647
J Thromb Haemost. 2020 May;18(5):1020-1022
pubmed: 32239799
Transpl Int. 2020 Jul;33(7):824-825
pubmed: 32236983
J Am Med Inform Assoc. 2006 May-Jun;13(3):353-5
pubmed: 16501183
BMJ. 2020 Apr 7;369:m1328
pubmed: 32265220
MMWR Morb Mortal Wkly Rep. 2020 Apr 03;69(13):382-386
pubmed: 32240123
Intensive Care Med. 2020 Jun;46(6):1114-1116
pubmed: 32236644
Lancet Infect Dis. 2020 May;20(5):533-534
pubmed: 32087114
PLoS One. 2013;8(3):e55811
pubmed: 23533569
Clin Chim Acta. 2020 Jun;505:190-191
pubmed: 32145275