Aberrant RNA Splicing in Cancer.
RNA
SF3B1
SRSF2
U2AF1
ZRSR2
splicing
Journal
Annual review of cancer biology
ISSN: 2472-3428
Titre abrégé: Annu Rev Cancer Biol
Pays: United States
ID NLM: 101686182
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
entrez:
1
9
2020
pubmed:
1
3
2019
medline:
1
3
2019
Statut:
ppublish
Résumé
RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression. Increased systematic sequencing of the genome and transcriptome of cancers has identified a variety of means by which RNA splicing is altered in cancer relative to normal cells. These findings, in combination with the discovery of recurrent change-of-function mutations in splicing factors in a variety of cancers, suggest that alterations in splicing are drivers of tumorigenesis. Greater characterization of altered splicing in cancer parallels increasing efforts to pharmacologically perturb splicing and early-phase clinical development of small molecules that disrupt splicing in patients with cancer. Here we review recent studies of global changes in splicing in cancer, splicing regulation of mitogenic pathways critical in cancer transformation, and efforts to therapeutically target splicing in cancer.
Identifiants
pubmed: 32864546
doi: 10.1146/annurev-cancerbio-030617-050407
pmc: PMC7453310
mid: NIHMS1038782
doi:
Types de publication
Journal Article
Langues
eng
Pagination
167-185Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA226342
Pays : United States
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