Effect of Pomegranate Extract in Mesenchymal Stem Cells by Modulation of microRNA-155, microRNA-21, microRNA-23b, microRNA-126a, and
Anti-Inflammatory Agents
/ pharmacology
Cells, Cultured
Humans
Mesenchymal Stem Cells
/ drug effects
MicroRNAs
/ genetics
NF-kappa B
/ genetics
Phosphatidylinositol 3-Kinases
/ genetics
Plant Extracts
/ pharmacology
Pomegranate
/ chemistry
Proto-Oncogene Proteins c-akt
/ genetics
Signal Transduction
immunoregulatory or immunomodulatory
mesenchymal stem cell
microRNA
pomegranate (Punica granatum)
Journal
DNA and cell biology
ISSN: 1557-7430
Titre abrégé: DNA Cell Biol
Pays: United States
ID NLM: 9004522
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
pubmed:
1
9
2020
medline:
21
10
2020
entrez:
1
9
2020
Statut:
ppublish
Résumé
Today, mesenchymal stem cells (MSCs) are candidates for various autoimmune disease treatments due to immunomodulatory activity in these cells. Much research has recently been done to improve the immunomodulatory activity of MSCs. Genetic variation is one of these methods. microRNAs (miRNAs) are small noncoding RNAs that control most of the cell's biological activities. Recent studies have shown that miRNAs play a significant role in the regulation of MSC immunomodulatory activity. Pomegranate is a fruit that has antioxidant, anti-inflammatory, and anticancer properties and has been used for many years for therapeutic purposes. The objective of this research is to evaluate the immunoregulatory-related miRNAs level of adipose-derived MSCs (Ad-MSCs) obtained from adipose tissue in the presence or lack of pomegranate (
Identifiants
pubmed: 32865424
doi: 10.1089/dna.2020.5775
doi:
Substances chimiques
Anti-Inflammatory Agents
0
MicroRNAs
0
NF-kappa B
0
Plant Extracts
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM