Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges.
Calcium
Cancer
Chloride
Immunotherapy
Inhibitors
Ion channels
Potassium
Sodium
Journal
Reviews of physiology, biochemistry and pharmacology
ISSN: 0303-4240
Titre abrégé: Rev Physiol Biochem Pharmacol
Pays: Germany
ID NLM: 0434624
Informations de publication
Date de publication:
2022
2022
Historique:
pubmed:
1
9
2020
medline:
7
5
2022
entrez:
1
9
2020
Statut:
ppublish
Résumé
Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety of processes such as maintenance of cellular osmolarity and membrane potential, motility (via interactions with the cytoskeleton), invasion, signal transduction, transcriptional activity and cell cycle progression, leading to tumour progression and metastasis. Ion channels thus represent promising targets for cancer therapy. Ion channels are attractive targets because many of them are expressed at the plasma membrane and a broad range of existing inhibitors are already in clinical use for other indications. However, many of the ion channels identified in cancer cells are also active in healthy normal cells, so there is a risk that certain blockers may have off-target effects on normal physiological function. This review describes recent research advances into ion channel inhibitors as anticancer therapeutics. A growing body of evidence suggests that a range of existing and novel Na
Substances chimiques
Ion Channels
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-43Subventions
Organisme : Medical Research Council
ID : MC_PC_16064
Pays : United Kingdom
Informations de copyright
© 2020. Springer Nature Switzerland AG.
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