The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury.
Betacoronavirus
/ immunology
Biomarkers
/ metabolism
Brain Injuries, Traumatic
/ diagnosis
COVID-19
Coronavirus Infections
/ complications
Humans
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
/ antagonists & inhibitors
Pandemics
Pneumonia, Viral
/ complications
Prognosis
Pyroptosis
SARS-CoV-2
NLRP3 inflammasome
SARS-CoV-2
neuroinflammation
pyroptosis
traumatic brain injury
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Aug 2020
27 Aug 2020
Historique:
received:
20
07
2020
revised:
25
08
2020
accepted:
26
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
12
9
2020
Statut:
epublish
Résumé
Traumatic brain injury (TBI) represents an important problem of global health. The damage related to TBI is first due to the direct injury and then to a secondary phase in which neuroinflammation plays a key role. NLRP3 inflammasome is a component of the innate immune response and different diseases, such as neurodegenerative diseases, are characterized by NLRP3 activation. This review aims to describe NLRP3 inflammasome and the consequences related to its activation following TBI. NLRP3, caspase-1, IL-1β, and IL-18 are significantly upregulated after TBI, therefore, the use of nonspecific, but mostly specific NLRP3 inhibitors is useful to ameliorate the damage post-TBI characterized by neuroinflammation. Moreover, NLRP3 and the molecules associated with its activation may be considered as biomarkers and predictive factors for other neurodegenerative diseases consequent to TBI. Complications such as continuous stimuli or viral infections, such as the SARS-CoV-2 infection, may worsen the prognosis of TBI, altering the immune response and increasing the neuroinflammatory processes related to NLRP3, whose activation occurs both in TBI and in SARS-CoV-2 infection. This review points out the role of NLRP3 in TBI and highlights the hypothesis that NLRP3 may be considered as a potential therapeutic target for the management of neuroinflammation in TBI.
Identifiants
pubmed: 32867310
pii: ijms21176204
doi: 10.3390/ijms21176204
pmc: PMC7503761
pii:
doi:
Substances chimiques
Biomarkers
0
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
NLRP3 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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