Gut Microbiota and Colon Cancer: A Role for Bacterial Protein Toxins?
DNA damage
bacterial infections
bacterial protein toxin
carcinogenesis
cell proliferation
colorectal neoplasms
gut microbiota
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Aug 2020
27 Aug 2020
Historique:
received:
27
07
2020
revised:
25
08
2020
accepted:
26
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Accumulating evidence indicates that the human intestinal microbiota can contribute to the etiology of colorectal cancer. Triggering factors, including inflammation and bacterial infections, may favor the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration. In this context, certain bacterial pathogens can exert a pro-tumoral activity by producing enzymatically-active protein toxins that either directly induce host cell DNA damage or interfere with essential host cell signaling pathways involved in cell proliferation, apoptosis, and inflammation. This review is focused on those toxins that, by mimicking carcinogens and cancer promoters, could represent a paradigm for bacterially induced carcinogenesis.
Identifiants
pubmed: 32867331
pii: ijms21176201
doi: 10.3390/ijms21176201
pmc: PMC7504354
pii:
doi:
Substances chimiques
Bacterial Toxins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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