Seropositivity to dengue and associated risk factors among non-malarias acute febrile patients in Arba Minch districts, southern Ethiopia.
Adolescent
Adult
Animals
Antibodies, Viral
/ blood
Cross-Sectional Studies
Dengue
/ blood
Dengue Virus
/ immunology
Ethiopia
/ epidemiology
Female
Fever
/ blood
Fluorescent Antibody Technique, Indirect
Humans
Immunoglobulin G
/ blood
Immunoglobulin M
/ blood
Male
Middle Aged
Prevalence
Risk Factors
Surveys and Questionnaires
Young Adult
Dengue virus
Febrile illness
Immunofluorescence
Seroprevalence
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
31 Aug 2020
31 Aug 2020
Historique:
received:
28
08
2019
accepted:
25
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Dengue fever is an arthropod vector-borne disease transmitted to humans by infected Aedes mosquitoes. Ethiopia has a favorable ecology for arthropods and report high burden of acute febrile illnesses. However, the contribution of arboviral infections to the burden of acute febrile illnesses is barely known. In this study the seropositivity to dengue virus infection and associated risk factors were assessed in Arba Minch districts, southern Ethiopia. An institution based cross-sectional study was conducted in a consecutive group of 529 acute febrile patients between May to August 2016. Socio-demographic data, residence place and clinical signs and symptoms were collected using structured questionnaires. Sera were tested for anti-dengue IgG and IgM using Euroimmune indirect immunofluorescent assay. Data analysis was done using SPSS V-20 (IBM Corp, 2012). P-value < 0.05 was taken as statistically significant. Seropositivity was 25.1% (133/529) and 8.1% (43/529) for anti- IgG and IgM respectively. The high IgM prevalence detected indicate the probability of active transmission with a potential of public health significance that calls for a proactive follow up of the communities in the study area to forecast and avert the risk.
Sections du résumé
BACKGROUND
BACKGROUND
Dengue fever is an arthropod vector-borne disease transmitted to humans by infected Aedes mosquitoes. Ethiopia has a favorable ecology for arthropods and report high burden of acute febrile illnesses. However, the contribution of arboviral infections to the burden of acute febrile illnesses is barely known. In this study the seropositivity to dengue virus infection and associated risk factors were assessed in Arba Minch districts, southern Ethiopia.
METHODS
METHODS
An institution based cross-sectional study was conducted in a consecutive group of 529 acute febrile patients between May to August 2016. Socio-demographic data, residence place and clinical signs and symptoms were collected using structured questionnaires. Sera were tested for anti-dengue IgG and IgM using Euroimmune indirect immunofluorescent assay. Data analysis was done using SPSS V-20 (IBM Corp, 2012). P-value < 0.05 was taken as statistically significant.
RESULT
RESULTS
Seropositivity was 25.1% (133/529) and 8.1% (43/529) for anti- IgG and IgM respectively.
CONCLUSION
CONCLUSIONS
The high IgM prevalence detected indicate the probability of active transmission with a potential of public health significance that calls for a proactive follow up of the communities in the study area to forecast and avert the risk.
Identifiants
pubmed: 32867694
doi: 10.1186/s12879-020-05370-3
pii: 10.1186/s12879-020-05370-3
pmc: PMC7460748
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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