Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system.
COVID-19
Coagulation
Inflammation
SARS-CoV2
Thrombosis
Journal
Blood reviews
ISSN: 1532-1681
Titre abrégé: Blood Rev
Pays: England
ID NLM: 8708558
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
31
03
2020
revised:
14
08
2020
accepted:
19
08
2020
pubmed:
2
9
2020
medline:
18
3
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
COVID-19 is a new pandemic, caused by Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-Cov2) infection and characterized by a broad spectrum of clinical manifestations. Inflammation and the innate immune system have been recently recognized as pivotal players in the most severe forms, characterized by significantly elevated levels of pro-inflammatory cytokines. In this setting, several studies have also reported the presence of abnormalities in coagulation parameters and platelets count, possibly identifying a subgroup of patients with poor prognosis. Some reports of full-blown thromboembolic events are emerging. Among the possible mechanisms underlying coagulation dysfunction, the so-called "cytokine storm" seems to play a pivotal role. Other candidate factors include virus-specific mechanisms, related to the virus interaction with renin angiotensin system (RAS) and the fibrinolytic pathway, but also comorbidities affecting these patients. Coagulation dysfunction is therefore a candidate risk factor for adverse outcomes in COVID-19 and should be carefully addressed in clinical practice.
Identifiants
pubmed: 32868115
pii: S0268-960X(20)30095-3
doi: 10.1016/j.blre.2020.100745
pmc: PMC7444609
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100745Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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