Capping protein is dispensable for polarized actin network growth and actin-based motility.
Arp2/3 complex
Ena/VASP proteins
actin
actin polymerization
biophysics
capping protein
cell motility
cytoskeleton
in vitro systems
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
06 11 2020
06 11 2020
Historique:
received:
26
06
2020
revised:
26
08
2020
pubmed:
2
9
2020
medline:
11
3
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
Heterodimeric capping protein (CP) binds the rapidly growing barbed ends of actin filaments and prevents the addition (or loss) of subunits. Capping activity is generally considered to be essential for actin-based motility induced by Arp2/3 complex nucleation. By stopping barbed end growth, CP favors nucleation of daughter filaments at the functionalized surface where the Arp2/3 complex is activated, thus creating polarized network growth, which is necessary for movement. However, here using an
Identifiants
pubmed: 32868296
pii: S0021-9258(17)50366-X
doi: 10.1074/jbc.RA120.015009
pmc: PMC7650241
pii:
doi:
Substances chimiques
Actin Capping Proteins
0
Actin-Related Protein 2-3 Complex
0
Actins
0
DNA-Binding Proteins
0
ENA-VASP proteins
0
Formins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15366-15375Informations de copyright
© 2020 Abou-Ghali et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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