Human γδ T cells recognize CD1b by two distinct mechanisms.
CD1b
Vd1
butyrophilin-like molecule
gd T cell
lipid antigen
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
pubmed:
2
9
2020
medline:
28
10
2020
entrez:
2
9
2020
Statut:
ppublish
Résumé
γδ T cells form an abundant part of the human cellular immune system, where they respond to tissue damage, infection, and cancer. The spectrum of known molecular targets recognized by Vδ1-expressing γδ T cells is becoming increasingly diverse. Here we describe human γδ T cells that recognize CD1b, a lipid antigen-presenting molecule, which is inducibly expressed on monocytes and dendritic cells. Using CD1b tetramers to study multiple donors, we found that many CD1b-specific γδ T cells use Vδ1. Despite their common use of Vδ1, three CD1b-specific γδ T cell receptors (TCRs) showed clear differences in the surface of CD1b recognized, the requirement for lipid antigens, and corecognition of butryophilin-like proteins. Several Vγ segments were present among the CD1b-specific TCRs, but chain swap experiments demonstrated that CD1b specificity was mediated by the Vδ1 chain. One of the CD1b-specific Vδ1
Identifiants
pubmed: 32868441
pii: 2010545117
doi: 10.1073/pnas.2010545117
pmc: PMC7502712
doi:
Substances chimiques
Antigens, CD1
0
CD1b antigen
0
Lipids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22944-22952Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI049313
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR048632
Pays : United States
Organisme : Wellcome Trust
ID : 106292/Z/14/Z
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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