Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging.
Adult
Age Factors
Aged
Aging
/ physiology
DNA Methylation
/ physiology
Epigenesis, Genetic
/ physiology
Exercise
/ physiology
Female
Humans
Leisure Activities
Male
Middle Aged
Models, Genetic
Occupational Health
Sex Factors
Smoking
/ adverse effects
Twins, Dizygotic
/ genetics
Twins, Monozygotic
/ genetics
Young Adult
Journal
Medicine and science in sports and exercise
ISSN: 1530-0315
Titre abrégé: Med Sci Sports Exerc
Pays: United States
ID NLM: 8005433
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
pubmed:
2
9
2020
medline:
22
6
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
Greater leisure-time physical activity (LTPA) associates with healthier lives, but knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA methylation (DNAm) patterns capture age-related changes in different tissues. We aimed to assess how LTPA and OPA are associated with three DNAm-based epigenetic age estimates, namely, DNAm age, PhenoAge, and GrimAge. The participants were young adult (21-25 yr, n = 285) and older (55-74 yr, n = 235) twin pairs, including 16 pairs with documented long-term LTPA discordance. Genome-wide DNAm from blood samples was used to compute DNAm age, PhenoAge, and GrimAge Age acceleration (Acc), which describes the difference between chronological and epigenetic ages. Physical activity was assessed with sport, leisure-time, and work indices based on the Baecke Questionnaire. Genetic and environmental variance components of epigenetic age Acc were estimated by quantitative genetic modeling. Epigenetic age Acc was highly heritable in young adult and older twin pairs (~60%). Sport index was associated with slower and OPA with faster DNAm GrimAge Acc after adjusting the model for sex. Genetic factors and nonshared environmental factors in common with sport index explained 1.5%-2.7% and 1.9%-3.5%, respectively, of the variation in GrimAge Acc. The corresponding proportions considering OPA were 0.4%-1.8% and 0.7%-1.8%, respectively. However, these proportions were minor (<0.5%) after adjusting the model for smoking status. LTPA associates with slower and OPA with faster epigenetic aging. However, adjusting the models for smoking status, which may reflect the accumulation of unhealthy lifestyle habits, attenuated the associations.
Identifiants
pubmed: 32868581
pii: 00005768-202103000-00004
doi: 10.1249/MSS.0000000000002498
pmc: PMC7886335
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
487-495Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL104125
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.
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