Matrix metalloproteinases in keratinocyte carcinomas.
basal cell carcinoma
extracellular matrix
fibroblasts
keratinocytes
matrix metalloproteinase
squamous cell carcinoma
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
04
07
2020
revised:
10
08
2020
accepted:
24
08
2020
pubmed:
2
9
2020
medline:
17
2
2022
entrez:
2
9
2020
Statut:
ppublish
Résumé
The incidence of cutaneous keratinocyte-derived cancers is increasing globally. Basal cell carcinoma (BCC) is the most common malignancy worldwide, and cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. BCC can be classified into subtypes based on the histology, and these subtypes are classified further into low- and high-risk tumors. There is an increasing need to identify new therapeutic strategies for the treatment of unresectable and metastatic cSCC, and for aggressive BCC variants such as infiltrating, basosquamous or morpheaform BCCs. The most important risk factor for BCC and cSCC is solar UV radiation, which causes genetic and epigenetic alterations in keratinocytes. Similar gene mutations are noted already in sun-exposed normal skin emphasizing the role of the alterations in the tumor microenvironment in the progression of cSCC. Early events in cSCC progression are alterations in the composition of basement membrane and dermal extracellular matrix induced by influx of microbes, inflammatory cells and activated stromal fibroblasts. Activated fibroblasts promote inflammation and produce growth factors and proteolytic enzymes, including matrix metalloproteinases (MMPs). Transforming growth factor-β produced by tumor cells and fibroblasts induces the expression of MMPs by cSCC cells and promotes their invasion. Fibroblast-derived keratinocyte growth factor suppresses the malignant phenotype of cSCC cells by inhibiting the expression of several MMPs. These findings emphasize the importance of interplay of tumor and stromal cells in the progression of cSCC and BCC and suggest tumor microenvironment as a therapeutic target in cSCC and aggressive subtypes of BCC.
Identifiants
pubmed: 32869366
doi: 10.1111/exd.14183
pmc: PMC7821196
doi:
Substances chimiques
Transforming Growth Factor beta
0
Fibroblast Growth Factor 7
126469-10-1
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
50-61Informations de copyright
© 2020 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.
Références
Acta Histochem. 2014 Jun;116(5):688-93
pubmed: 24485332
Clin Cancer Res. 2010 Apr 1;16(7):2022-35
pubmed: 20305301
Expert Opin Investig Drugs. 2000 Dec;9(12):2913-22
pubmed: 11093361
Am J Transplant. 2013 Jan;13(1):119-29
pubmed: 23072567
Clin Cancer Res. 2015 Mar 15;21(6):1447-56
pubmed: 25589618
J Invest Dermatol. 1994 Oct;103(4):482-7
pubmed: 7930671
J Am Acad Dermatol. 1992 Jun;26(6):976-90
pubmed: 1607418
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Apr;119(4):459-67
pubmed: 25697929
Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947
pubmed: 30371878
J Invest Dermatol. 2003 Nov;121(5):997-1004
pubmed: 14708598
Environ Toxicol. 2020 Jun;35(6):673-682
pubmed: 31995279
Mol Biol Rep. 2016 Oct;43(10):1027-33
pubmed: 27406386
Mod Pathol. 2004 May;17(5):496-502
pubmed: 14990972
Clin Cancer Res. 2009 Jan 15;15(2):425-30
pubmed: 19147746
Annu Rev Cell Dev Biol. 2001;17:463-516
pubmed: 11687497
Sci Rep. 2018 Feb 8;8(1):2660
pubmed: 29422610
Drug Des Devel Ther. 2020 Apr 03;14:1363-1375
pubmed: 32308369
Nat Commun. 2016 Aug 30;7:12601
pubmed: 27574101
J Cell Sci. 2002 Oct 1;115(Pt 19):3719-27
pubmed: 12235282
Cancer. 2017 Jun 1;123(11):2054-2060
pubmed: 28171708
Acta Derm Venereol. 2016 Jan;96(1):3-16
pubmed: 26084328
J Surg Oncol. 2008 Jun 1;97(7):615-20
pubmed: 18404670
Genes Dev. 2007 Mar 1;21(5):562-77
pubmed: 17344417
J Natl Cancer Inst. 2015 Oct 16;108(1):
pubmed: 26476432
Br J Dermatol. 2000 Sep;143(3):513-9
pubmed: 10971322
Oncol Lett. 2018 Sep;16(3):4064-4072
pubmed: 30128029
Int J Cancer. 2002 May 10;99(2):157-66
pubmed: 11979428
Anticancer Res. 2018 Feb;38(2):771-778
pubmed: 29374701
Nat Cell Biol. 2008 Aug;10(8):902-11
pubmed: 18604200
JAMA Dermatol. 2015 Oct;151(10):1081-6
pubmed: 25928283
Int J Cancer. 2003 Mar 1;103(6):709-16
pubmed: 12516088
Exp Dermatol. 2008 Apr;17(4):349-55
pubmed: 17979968
Lancet. 2010 Feb 20;375(9715):673-85
pubmed: 20171403
Br J Dermatol. 2019 Sep;181(3):474-482
pubmed: 30864158
Pathol Res Pract. 2013 Nov;209(11):705-9
pubmed: 24011615
J Invest Dermatol. 2014 May;134(5):1418-1427
pubmed: 24270662
Cancer Metastasis Rev. 2006 Mar;25(1):9-34
pubmed: 16680569
Exp Mol Pathol. 2012 Apr;92(2):236-42
pubmed: 22305927
Photochem Photobiol. 2009 May-Jun;85(3):652-62
pubmed: 19076306
Cell. 2010 Apr 2;141(1):52-67
pubmed: 20371345
JAMA Dermatol. 2019 Mar 1;155(3):298-306
pubmed: 30484823
Virchows Arch. 2008 Jan;452(1):83-90
pubmed: 18034264
Cancer Discov. 2011 Jul;1(2):137-43
pubmed: 21984974
Amino Acids. 2011 Jul;41(2):271-90
pubmed: 20640864
J Cell Sci. 2000 Jan;113 Pt 2:227-35
pubmed: 10633074
Am J Pathol. 1997 Aug;151(2):499-508
pubmed: 9250162
Sci Transl Med. 2018 Aug 22;10(455):
pubmed: 30135250
Science. 1989 Aug 18;245(4919):752-5
pubmed: 2475908
J Biol Chem. 1994 Apr 8;269(14):10753-7
pubmed: 7511604
Oncogene. 2007 Apr 12;26(17):2491-501
pubmed: 17099730
Acta Derm Venereol. 2013 Nov;93(6):663-8
pubmed: 23572151
Am J Clin Dermatol. 2016 Oct;17(5):491-508
pubmed: 27358187
Trends Pharmacol Sci. 2013 Apr;34(4):233-42
pubmed: 23541335
J Am Acad Dermatol. 2018 Feb;78(2):237-247
pubmed: 29332704
Science. 2015 May 22;348(6237):880-6
pubmed: 25999502
Nat Commun. 2015 Jan 09;6:5932
pubmed: 25575023
Br J Cancer. 2001 Mar 2;84(5):659-69
pubmed: 11237387
Pathol Res Pract. 2013 Oct;209(10):627-34
pubmed: 23948694
J Invest Dermatol. 2015 May;135(5):1275-1282
pubmed: 25347116
J Invest Dermatol. 2005 Apr;124(4):849-56
pubmed: 15816845
FASEB J. 2001 Apr;15(6):898-906
pubmed: 11292649
Nat Commun. 2018 Sep 10;9(1):3667
pubmed: 30202019
Oncogene. 2004 Jul 1;23(30):5111-23
pubmed: 15094779
Exp Dermatol. 2021 Jan;30(1):50-61
pubmed: 32869366
Br J Dermatol. 2017 Nov;177(5):1208-1216
pubmed: 28994104
Graefes Arch Clin Exp Ophthalmol. 2012 Mar;250(3):425-31
pubmed: 21881840
Mol Carcinog. 1994 Sep;11(1):29-33
pubmed: 7916987
ScientificWorldJournal. 2013;2013:920595
pubmed: 23365550
Indian J Pathol Microbiol. 2011 Jul-Sep;54(3):526-31
pubmed: 21934214
Am J Pathol. 2020 Feb;190(2):503-517
pubmed: 31837949
JAMA Dermatol. 2017 Mar 1;153(3):296-303
pubmed: 28097368
Exp Dermatol. 2016 May;25(5):348-54
pubmed: 26660139
J Cancer Res Ther. 2013 Oct-Dec;9(4):613-7
pubmed: 24518705
Front Oncol. 2015 Oct 14;5:214
pubmed: 26528429
Lab Invest. 2003 Dec;83(12):1887-99
pubmed: 14691307
J Invest Dermatol. 2014 Oct;134(10):2630-2638
pubmed: 24662767
J Invest Dermatol. 1996 Feb;106(2):321-6
pubmed: 8601735
Cancer Res. 1992 Mar 1;52(5):1336-41
pubmed: 1310643
Matrix Biol. 2015 May-Jul;44-46:184-90
pubmed: 25661772
Exp Dermatol. 2003 Apr;12(2):109-25
pubmed: 12702139
Science. 1994 Nov 4;266(5186):819-22
pubmed: 7973639
J Exp Med. 1995 Nov 1;182(5):1369-76
pubmed: 7595207
Exp Dermatol. 2009 Dec;18(12):1044-52
pubmed: 19601983
J Invest Dermatol. 2009 Dec;129(12):2886-94
pubmed: 19571820
Cell Mol Life Sci. 2009 Jan;66(2):203-24
pubmed: 18810321
Cancer Res. 2016 Feb 15;76(4):940-51
pubmed: 26676755
Exp Dermatol. 2010 Jun;19(6):473-82
pubmed: 20482618
Arch Facial Plast Surg. 2005 Jul-Aug;7(4):238-43
pubmed: 16027344
Eur J Biochem. 1997 Dec 15;250(3):751-7
pubmed: 9461298
Eur J Dermatol. 2001 Nov-Dec;11(6):530-3
pubmed: 11701402
J Invest Dermatol. 2011 Jun;131(6):1322-30
pubmed: 21307877
PLoS One. 2012;7(3):e33041
pubmed: 22427941
Int J Cancer. 2007 Nov 15;121(10):2119-24
pubmed: 17849476
World J Clin Oncol. 2013 Nov 10;4(4):85-90
pubmed: 24926428
Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2006-11
pubmed: 15598755
Acta Derm Venereol. 2020 Sep 23;100(16):adv00266
pubmed: 32930344
Am J Clin Oncol. 2020 May;43(5):366-370
pubmed: 32217856
Int J Mol Sci. 2019 Jul 19;20(14):
pubmed: 31331124
Nat Rev Immunol. 2004 Aug;4(8):617-29
pubmed: 15286728
Oncogene. 1994 Nov;9(11):3199-204
pubmed: 7936642
Rom J Morphol Embryol. 2013;54(4):939-51
pubmed: 24398989
J Am Acad Dermatol. 2015 Aug;73(2):221-7
pubmed: 26028524
N Engl J Med. 2018 Jul 26;379(4):363-374
pubmed: 30044931
Toxicol Appl Pharmacol. 2017 Aug 15;329:212-223
pubmed: 28610992
Br J Dermatol. 2005 Apr;152(4):720-6
pubmed: 15840104
Cell Mol Life Sci. 2020 Nov;77(22):4601-4614
pubmed: 32462404
Ann Dermatol. 2013 May;25(2):145-51
pubmed: 23717003
Biochim Biophys Acta. 2014 Aug;1840(8):2571-80
pubmed: 24631662
J Am Acad Dermatol. 2013 Jan;68(1 Suppl 1):S10-9
pubmed: 23228301
Clin Exp Dermatol. 1999 Mar;24(2):122-6
pubmed: 10233668
FEBS J. 2011 Jan;278(1):16-27
pubmed: 21087457
Pathol Res Pract. 2016 Oct;212(10):867-871
pubmed: 27567711
Carcinogenesis. 2005 Oct;26(10):1657-67
pubmed: 15905207
Br J Dermatol. 2017 Aug;177(2):373-381
pubmed: 28211039
J Invest Dermatol. 2007 Jan;127(1):49-59
pubmed: 16917496
Br J Dermatol. 2011 Dec;165(6):1197-204
pubmed: 21729023
J Dermatol. 2015 Sep;42(9):881-8
pubmed: 26047064
Eur J Biochem. 1997 Sep 1;248(2):369-73
pubmed: 9346290
Br J Dermatol. 2010 Oct;163(4):726-35
pubmed: 20586780
Histopathology. 2007 Dec;51(6):793-804
pubmed: 18042068
Clin Cancer Res. 2014 Dec 15;20(24):6582-92
pubmed: 25303977
J Biol Chem. 1996 Jan 19;271(3):1544-50
pubmed: 8576151
Mol Biotechnol. 2003 Jun;24(2):157-202
pubmed: 12746556
Br J Dermatol. 2008 Apr;158(4):778-85
pubmed: 18284387
Int J Biochem Cell Biol. 2014 Aug;53:450-8
pubmed: 24955488
Tumour Biol. 2013 Aug;34(4):2041-51
pubmed: 23681802
Cancer. 2016 Jan 15;122(2):249-57
pubmed: 26479420
J Invest Dermatol. 2005 Jun;124(6):1162-9
pubmed: 15955090
Matrix Biol. 2020 May;87:26-47
pubmed: 31655292
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1927-1939
pubmed: 28636874
In Vivo. 2020 May-Jun;34(3):1271-1275
pubmed: 32354918
JAMA Dermatol. 2015 Nov;151(11):1220-5
pubmed: 26177278
Cancer Cell. 2016 May 9;29(5):622-637
pubmed: 27165741
Science. 2002 Apr 26;296(5568):747-9
pubmed: 11976459
J Invest Dermatol. 1997 Aug;109(2):225-31
pubmed: 9242512
J Histochem Cytochem. 1998 Apr;46(4):437-47
pubmed: 9524189
Cancer Metastasis Rev. 2019 Dec;38(4):829-837
pubmed: 31802358
J Clin Invest. 2012 Feb;122(2):464-72
pubmed: 22293185
BMC Cancer. 2013 Feb 05;13:58
pubmed: 23379751
J Dermatol. 2006 Sep;33(9):609-15
pubmed: 16958805
Biochimie. 2005 Mar-Apr;87(3-4):273-86
pubmed: 15781314
Front Biosci. 2006 Jan 01;11:529-43
pubmed: 16146751
Int J Mol Sci. 2019 May 02;20(9):
pubmed: 31052530
Exp Dermatol. 1997 Oct;6(5):199-213
pubmed: 9450622
J Invest Dermatol. 2002 Jul;119(1):14-21
pubmed: 12164918
Cell Tissue Res. 2016 Sep;365(3):691-702
pubmed: 27411692
Oncogene. 2007 Aug 9;26(36):5267-79
pubmed: 17334397
Int J Surg Pathol. 2015 Feb;23(1):20-5
pubmed: 24984957
Nat Rev Clin Oncol. 2016 Oct;13(10):611-26
pubmed: 27118493
Oncogene. 2006 Apr 27;25(18):2588-600
pubmed: 16407850
Anticancer Res. 1999 Jul-Aug;19(4B):2929-38
pubmed: 10652575
Exp Mol Pathol. 2003 Jun;74(3):230-7
pubmed: 12782009
J Invest Dermatol. 2000 Jun;114(6):1113-9
pubmed: 10844553
Exp Mol Pathol. 2005 Oct;79(2):151-60
pubmed: 16004981