Alzheimer's disease biomarkers as predictors of trajectories of depression and apathy in cognitively normal individuals, mild cognitive impairment, and Alzheimer's disease dementia.
Alzheimer's disease
apathy
cerebrospinal fluid biomarkers
depression
mild cognitive impairment
neurocognitive disorders
Journal
International journal of geriatric psychiatry
ISSN: 1099-1166
Titre abrégé: Int J Geriatr Psychiatry
Pays: England
ID NLM: 8710629
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
30
10
2019
revised:
08
07
2020
accepted:
14
08
2020
pubmed:
2
9
2020
medline:
24
4
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
To examine trajectories of depression and apathy over a 5-year follow-up period in (prodromal) Alzheimer's disease (AD), and to relate these trajectories to AD biomarkers. The trajectories of depression and apathy (measured with the Neuropsychiatric Inventory or its questionnaire) were separately modeled using growth mixture models for two cohorts (National Alzheimer's Coordinating Center, NACC, n = 22 760 and Alzheimer's Disease Neuroimaging Initiative, ADNI, n = 1 733). The trajectories in ADNI were associated with baseline CSF AD biomarkers (Aβ Multiple classes were identified, with the largest classes having no symptoms over time. Lower Aβ The trajectories of depression and apathy in individuals on the AD spectrum are associated with AD biomarkers.
Identifiants
pubmed: 32869375
doi: 10.1002/gps.5418
pmc: PMC8140398
mid: NIHMS1667476
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Peptide Fragments
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
224-234Subventions
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047266
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG025688
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005133
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005138
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NIA NIH HHS
ID : P50 AG047366
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028383
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG033514
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG053760
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010124
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005131
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005146
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG072122
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG035982
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG008702
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG016976
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG008051
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013846
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047270
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005136
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG012300
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005134
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG008017
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062715
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
J Affect Disord. 2017 Nov;222:146-152
pubmed: 28704802
Neurology. 1994 Dec;44(12):2308-14
pubmed: 7991117
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
Am J Psychiatry. 2018 Jun 1;175(6):530-537
pubmed: 29325447
Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):351-358
pubmed: 30376508
Alzheimers Dement. 2013 Sep;9(5):488-98
pubmed: 23159046
Ann Neurol. 2009 Apr;65(4):403-13
pubmed: 19296504
Alzheimer Dis Assoc Disord. 2007 Jul-Sep;21(3):249-58
pubmed: 17804958
Tijdschr Psychiatr. 2010;52(6):397-405
pubmed: 20544597
Am J Geriatr Psychiatry. 2011 Jun;19(6):532-42
pubmed: 21606896
Dement Geriatr Cogn Disord. 2008;25(2):115-26
pubmed: 18087152
Int J Geriatr Psychiatry. 2018 Feb;33(2):405-413
pubmed: 28736899
J Neuropathol Exp Neurol. 2011 Nov;70(11):960-9
pubmed: 22002422
Am J Geriatr Psychiatry. 2014 Nov;22(11):1168-79
pubmed: 23890751
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Alcohol Clin Exp Res. 2000 Jun;24(6):882-91
pubmed: 10888079
Dement Geriatr Cogn Disord. 2007;24(6):457-63
pubmed: 17986816
J Alzheimers Dis. 2010;22(4):1169-80
pubmed: 20930287
Am J Geriatr Psychiatry. 2016 Jan;24(1):70-80
pubmed: 26525995
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Neurosci Biobehav Rev. 2019 Dec;107:346-359
pubmed: 31525387