Race, Ancestry, and Vitamin D Metabolism: The Multi-Ethnic Study of Atherosclerosis.
Aged
Atherosclerosis
/ ethnology
Biomarkers
/ blood
Cohort Studies
Cross-Sectional Studies
Ethnicity
/ statistics & numerical data
Female
Humans
Male
Middle Aged
Parathyroid Hormone
/ blood
Racial Groups
/ statistics & numerical data
Risk Factors
United States
/ epidemiology
Vitamin D
/ analogs & derivatives
Vitamin D Deficiency
/ ethnology
Vitamin D-Binding Protein
/ blood
ancestry
mineral metabolism
parathyroid hormone
race
vitamin d
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
10
07
2020
accepted:
27
08
2020
pubmed:
2
9
2020
medline:
2
3
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
A comprehensive characterization of racial/ethnic variations in vitamin D metabolism markers may improve our understanding of differences in bone and mineral homeostasis and the risk of vitamin D-related diseases. Describe racial/ethnic differences in vitamin D metabolism markers and their associations with genetic ancestry. In a cross-sectional study within the Multi-Ethnic Study of Atherosclerosis (MESA), we compared a comprehensive panel of vitamin D metabolism markers across self-reported racial/ethnic groups of Black (N = 1759), White (N = 2507), Chinese (N = 788), and Hispanic (N = 1411). We evaluated associations of proportion African and European ancestry with this panel of markers in Black and Hispanic participants using ancestry informative markers. Latent class analysis evaluated associations between patterns of vitamin D measurements with race/ethnicity. Compared with Black participants, White participants had significantly higher serum concentrations of 25-hydroxyvitamin D and fibroblast growth factor-23; lower concentrations of parathyroid hormone and 1,25-dihydroxyvitamin D; circulating vitamin D metabolite ratios suggesting lower CYP27B1 and higher CYP24A1 activity; higher urinary concentrations of calcium and phosphorus with higher urinary fractional excretion of phosphorus; and differences in vitamin D binding globulin haplotypes. Higher percent European ancestry was associated with higher 25-hydroxyvitamin D and lower parathyroid hormone concentrations among Black and Hispanic participants. Latent classes defined by vitamin D measurements reflected these patterns and differed significantly by race/ethnicity and ancestry. Markers of vitamin D metabolism vary significantly by race/ethnicity, may serve to maintain bone and mineral homeostasis across ranges of 25-hydroxyvitamin D production, and be attributable, at least partly, to genetic ancestry.
Identifiants
pubmed: 32869845
pii: 5900058
doi: 10.1210/clinem/dgaa612
pmc: PMC7526733
pii:
doi:
Substances chimiques
Biomarkers
0
Parathyroid Hormone
0
Vitamin D-Binding Protein
0
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDA NIH HHS
ID : 75N95020D00003
Pays : United States
Organisme : CLC NIH HHS
ID : 75N90020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00007
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95163
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95162
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95165
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000040
Pays : United States
Organisme : NIH HHS
ID : 75N98020D00007
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95166
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007467
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL096875
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00004
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003C
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK088762
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NIEHS NIH HHS
ID : 75N96020D00002
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00003
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95168
Pays : United States
Organisme : CLC NIH HHS
ID : 75N90020D00003
Pays : United States
Organisme : NIEHS NIH HHS
ID : 75N96020D00003
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK109019
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00006
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95159
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00007
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95161
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020D00005
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK035816
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00005
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95167
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92021D00006
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099199
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056336
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00007
Pays : United States
Organisme : ORFDO NIH HHS
ID : 75N99020D00004
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Informations de copyright
© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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