First Trimester DEX Treatment Is Not Associated with Altered Brain Activity During Working Memory Performance in Adults.
Adolescent
Adrenal Hyperplasia, Congenital
/ prevention & control
Brain
/ diagnostic imaging
Dexamethasone
/ administration & dosage
Female
Glucocorticoids
/ administration & dosage
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
/ drug effects
Neuropsychological Tests
Pregnancy
Pregnancy Trimester, First
Prenatal Exposure Delayed Effects
/ diagnostic imaging
Young Adult
brain function
cortisol
dexamethasone
prenatal glucocorticoid treatment
working memory
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
received:
01
07
2020
accepted:
28
08
2020
pubmed:
2
9
2020
medline:
17
2
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
Prenatal dexamethasone (DEX) treatment is sometimes used in pregnancies at risk for congenital adrenal hyperplasia (CAH) to prevent virilization in female fetuses with CAH. In boys and in fetuses not having CAH, there is no benefit of early DEX treatment and the risks of this therapy must be thoroughly investigated. High doses of prenatal glucocorticoid might alter the developmental trajectory of the brain into adulthood, even for CAH unaffected subjects treated with DEX for a short term during the first trimester. The present study investigated brain activation during working memory performance in DEX-treated subjects compared with controls. We tested 18 participants who were exposed to DEX during the first trimester of fetal life but did not have CAH (8 females; mean age 20.78 [standard deviation (SD), 2.67] years) and 40 control participants (24 females; mean age 20.53 [SD, 2.64]) from a single research institute. Participants underwent functional magnetic resonance imaging on a 3T scanner during a verbal and visuospatial working memory task. We did not observe any differences in brain activity during working memory performance. However, DEX-treated subjects responded faster during the experimental condition of the verbal WM task. First trimester DEX treatment did not seem to result in altered working memory-related brain activity at adult age. Our findings contribute to the risk-benefit assessment of prenatal DEX treatment in the context of CAH.
Identifiants
pubmed: 32869847
pii: 5900055
doi: 10.1210/clinem/dgaa611
pmc: PMC7510958
pii:
doi:
Substances chimiques
Glucocorticoids
0
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Endocrine Society 2020.
Références
Epigenetics. 2015;10(5):408-17
pubmed: 25875334
Biol Psychiatry. 2013 Nov 1;74(9):647-55
pubmed: 23611262
Neuroimage. 2006 Jul 15;31(4):1673-81
pubmed: 16616520
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
pubmed: 11293691
J Clin Endocrinol Metab. 2007 Feb;92(2):542-8
pubmed: 17148562
Dev Psychopathol. 2019 May;31(2):419-431
pubmed: 29606180
Neuroscience. 2019 Jun 1;408:22-30
pubmed: 30926550
Transl Psychiatry. 2017 Jun 13;7(6):e1153
pubmed: 28608856
Endocr Rev. 2000 Jun;21(3):245-91
pubmed: 10857554
Clin Endocrinol (Oxf). 2017 Dec;87(6):651-659
pubmed: 28771762
J Clin Endocrinol Metab. 2002 Nov;87(11):5119-24
pubmed: 12414881
Psychoneuroendocrinology. 2010 Jan;35(1):141-53
pubmed: 19674845
J Clin Endocrinol Metab. 2016 Oct;101(10):3838-3846
pubmed: 27482827
Psychiatry Res Neuroimaging. 2019 Mar 30;285:51-57
pubmed: 30771753
Biol Psychiatry. 2018 Jan 15;83(2):109-119
pubmed: 28754515
Neuroimage. 2019 Jan 1;184:697-706
pubmed: 30268847
Best Pract Res Clin Endocrinol Metab. 2015 Jun;29(3):469-83
pubmed: 26051303
Endocr Res. 1989;15(1-2):277-301
pubmed: 2667968
Neuropsychologia. 2008 Sep;46(11):2668-82
pubmed: 18573510
Brain Res Bull. 2005 Nov 15;67(5):403-12
pubmed: 16216687
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
Toxicol Lett. 2020 Oct 1;331:33-41
pubmed: 32445661
J Endocr Soc. 2018 Dec 12;3(1):250-263
pubmed: 30623163
Hum Brain Mapp. 2002 Nov;17(3):143-55
pubmed: 12391568
Neuroimage. 2004 Apr;21(4):1732-47
pubmed: 15050594
Neuroimage. 2015 May 15;112:278-287
pubmed: 25770990
J Clin Endocrinol Metab. 2018 Nov 1;103(11):4043-4088
pubmed: 30272171
Psychoneuroendocrinology. 2018 May;91:68-74
pubmed: 29529521
JAMA Pediatr. 2014 Jun;168(6):567-74
pubmed: 24733564
Neuroimage. 2001 Dec;14(6):1370-86
pubmed: 11707093
Pediatr Endocrinol Rev. 2018 Sep;16(1):186-193
pubmed: 30371037
Neuroimage. 2015 May 15;112:267-277
pubmed: 25770991