Effectiveness of Scutellaria barbata water extract on inhibiting colon tumor growth and metastasis in tumor-bearing mice.
Animals
Apigenin
/ pharmacology
Cell Line, Tumor
Colonic Neoplasms
/ drug therapy
Drugs, Chinese Herbal
/ therapeutic use
Glucuronates
/ pharmacology
Humans
Male
Mice
Mice, Nude
Neoplasm Metastasis
/ prevention & control
Plant Extracts
/ therapeutic use
Scutellaria
/ chemistry
Signal Transduction
/ drug effects
Xenograft Model Antitumor Assays
Scutellaria barbata
chemical marker
colon cancer
metastasis
scutellarin
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
11
02
2020
revised:
19
06
2020
accepted:
24
06
2020
pubmed:
2
9
2020
medline:
24
2
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
The plant Scutellaria barbata (SB) is commonly used as herbal medicines for treating cancer. The present pre-clinical study aimed to validate the Chinese Pharmacopoeia (CP) recommended dosages of SB water extract (SBW) in treating colon tumors. The content of chemical marker scutellarin in SBW was quantified using UPLC. Mice bearing human HCT116 xenografts or murine colon26 tumors received oral administration of SBW or scutellarin for 4 weeks. Results showed that SBW (615 and 1,230 mg/kg) and scutellarin (7 mg/kg) treatments significantly reduced human xenograft weights by 28.7, 36.9 and 28.8%, respectively. Lung metastasis area could be ameliorated after SBW (615 mg/kg) and scutellarin (7 mg/kg) treatments by 23.4 and 29.5%, respectively. Expressions of colon cancer metastasis-related proteins E-cadherin, Tspan 8 and CXCR4, as well as Src kinase in tumors were first shown to be regulated by SBW. Furthermore, in murine colon26 tumor-bearing mice, SBW (615 mg/kg) and scutellarin (7 mg/kg) treatments reduced the orthotopic tumor burden by 94.7% and lung metastatic tumor burden by 94.1%, respectively. Our findings provided evidences that SBW (at the mouse equivalent dosages to clinical dosages recommended by CP) could exert anti-tumor and anti-metastatic effects in colon cancer animal models.
Substances chimiques
Drugs, Chinese Herbal
0
Glucuronates
0
Plant Extracts
0
Scutellaria barbata extract
0
scutellarin
16IGP0ML9A
Apigenin
7V515PI7F6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
361-373Subventions
Organisme : Key Technologies R&D Program
ID : 2017YFE0190900; Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine, The Chinese University of Hong Kong
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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