Population Pharmacokinetics of Methadone after Oral Administration in Japanese Patients with Cancer-Related Pain.
ALBI (albumin-bilirubin) score
Methadone
cancer
pain
population pharmacokinetics
Journal
Journal of pain & palliative care pharmacotherapy
ISSN: 1536-0539
Titre abrégé: J Pain Palliat Care Pharmacother
Pays: England
ID NLM: 101125608
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
2
9
2020
medline:
29
10
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
Methadone tablets were approved for use in Japan in March 2013. The metabolism of methadone is complex and executed mainly by the cytochromes, CYP3A4 and CYP2B6. The aim of this study was to evaluate the pharmacokinetics of methadone upon oral administration in Japanese patients who experienced cancer-related pain. The concentration of the drug in blood samples was measured in 25 patients undergoing methadone therapy, and the factors leading to variations were investigated. A population pharmacokinetic analysis was evaluated using the Phoenix® NLME
Identifiants
pubmed: 32870067
doi: 10.1080/15360288.2020.1785070
doi:
Substances chimiques
Methadone
UC6VBE7V1Z
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM