The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity.
Chelator
Dopaminergic neurons
LUHMES
MT1G
Metal metabolism
Metallothionein
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
30
04
2020
accepted:
10
08
2020
revised:
19
07
2020
pubmed:
2
9
2020
medline:
21
8
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
Identification of toxicants that underlie neurological diseases is a neglected area awaiting a valid strategy to identify such toxicants. We sought biomarkers that respond to known neurotoxicants in LUHMES immortalized neurons and evaluated these biomarkers for use in screening libraries of environmental toxicants. LUHMES immortalized human dopaminergic neurons were surveyed by RNA sequencing following challenge with parkinsonian toxicants rotenone, 6-hydroxydopamine, MPP+, and ziram (zinc dimethyldithiocarbamate; Zn
Identifiants
pubmed: 32870474
doi: 10.1007/s12640-020-00272-3
pii: 10.1007/s12640-020-00272-3
pmc: PMC7765730
mid: NIHMS1647142
doi:
Substances chimiques
Biomarkers
0
Guanidines
0
Hazardous Substances
0
MT1G protein, human
0
Neonicotinoids
0
Nitro Compounds
0
dinotefuran
1W509710WF
Metallothionein
9038-94-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
967-978Subventions
Organisme : Intramural NIH HHS
ID : Z99 TR999999
Pays : United States
Organisme : NCATS NIH HHS
ID : Intramural support
Pays : United States
Organisme : NIEHS NIH HHS
ID : Tox21 MoA
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIC TR000039
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA TR000039
Pays : United States
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