Brain-derived neurotropic factor and cortisol levels negatively predict working memory performance in healthy males.
Acute stress
BDNF
Brain-derived neurotrophic factor
Cortisol
Working memory
Journal
Neurobiology of learning and memory
ISSN: 1095-9564
Titre abrégé: Neurobiol Learn Mem
Pays: United States
ID NLM: 9508166
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
03
03
2020
revised:
31
07
2020
accepted:
26
08
2020
pubmed:
2
9
2020
medline:
28
9
2021
entrez:
2
9
2020
Statut:
ppublish
Résumé
There is now significant literature suggesting that increasing brain-derived neurotropic factor (BDNF) signalling may improve memory-related disorders such as Alzheimer's disease. However, the effects of BDNF on short-term and working memory are not clear and existing evidence is inconsistent. Here we measured plasma BDNF and salivary cortisol levels, as well as working memory, on an N-Back task before and after mixed psychosocial/physiological stress induction in healthy males (N = 29). Stress induction was associated with higher circulating cortisol, but not BDNF levels. Higher cortisol and BDNF levels were significantly associated with poorer accuracy before and after stress induction. There was also a significant interaction, such that higher BDNF was associated with a buffering effect on the negative association between high cortisol and working memory. Future studies should replicate this data in larger samples, with emphasis on cortisol/BDNF interactions in determining working memory performance.
Identifiants
pubmed: 32871254
pii: S1074-7427(20)30152-0
doi: 10.1016/j.nlm.2020.107308
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107308Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.