Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy

Administration, Oral Denervation Diterpenes Humans Muscle Fibers, Skeletal / pathology Muscle, Skeletal / pathology Muscular Atrophy / etiology
Atrogin-1 Geranylgeraniol skeletal muscle atrophy

Journal

In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809

Informations de publication

Date de publication:
Historique:
received: 19 05 2020
revised: 04 06 2020
accepted: 05 06 2020
entrez: 3 9 2020
pubmed: 3 9 2020
medline: 22 6 2021
Statut: ppublish

Résumé

Geranylgeraniol (GGOH), a C20 isoprenoid naturally occurs in several foods. We previously reported that GGOH treatment reduced the expression levels of Atrogin-1 which is involved in skeletal muscle degradation and stimulates the myogenic differentiation of C2C12 myoblasts. However, the effect of GGOH supplementation on skeletal muscle metabolism in vivo is unknown. Skeletal muscle atrophy was induced by denervation. The expression levels of Atrogin-1 were assessed by western blotting or real time PCR. Intraoral administration of GGOH reduced the decrease in the cross-sectional area of muscle fibers and also suppressed the expression levels of Atrogin-1 in denervation induced muscle atrophy. Also, GGOH treatment suppressed the expression of Atrogin-1 and the decrease in skeletal muscle fiber size by glucocorticoid in vitro. Intraoral administration of GGOH rescues denervation-induced muscle atrophy via suppression of Atrogin-1.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
Geranylgeraniol (GGOH), a C20 isoprenoid naturally occurs in several foods. We previously reported that GGOH treatment reduced the expression levels of Atrogin-1 which is involved in skeletal muscle degradation and stimulates the myogenic differentiation of C2C12 myoblasts. However, the effect of GGOH supplementation on skeletal muscle metabolism in vivo is unknown.
MATERIALS AND METHODS METHODS
Skeletal muscle atrophy was induced by denervation. The expression levels of Atrogin-1 were assessed by western blotting or real time PCR.
RESULTS RESULTS
Intraoral administration of GGOH reduced the decrease in the cross-sectional area of muscle fibers and also suppressed the expression levels of Atrogin-1 in denervation induced muscle atrophy. Also, GGOH treatment suppressed the expression of Atrogin-1 and the decrease in skeletal muscle fiber size by glucocorticoid in vitro.
CONCLUSION CONCLUSIONS
Intraoral administration of GGOH rescues denervation-induced muscle atrophy via suppression of Atrogin-1.

Identifiants

DOI: 10.21873/invivo.12047 PMID: 32871759 PMC: PMC7652489
pubmed: 32871759
pii: 34/5/2345
doi: 10.21873/invivo.12047
pmc: PMC7652489
doi:

Substances chimiques

Diterpenes 0
geranylgeraniol AIA02AJA3A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2345-2351

Informations de copyright

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Références

JAMA. 2003 Apr 2;289(13):1681-90
pubmed: 12672737
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14440-5
pubmed: 11717410
Curr Opin Genet Dev. 2005 Feb;15(1):62-8
pubmed: 15661535
PLoS One. 2011 Jan 13;6(1):e16171
pubmed: 21249144
N Engl J Med. 1996 Dec 19;335(25):1897-905
pubmed: 8948566
J Clin Invest. 2006 Nov;116(11):2945-54
pubmed: 17080195
FASEB J. 2009 Feb;23(2):362-70
pubmed: 18827022
In Vivo. 2018 Nov-Dec;32(6):1427-1431
pubmed: 30348697
Free Radic Biol Med. 2008 Jan 15;44(2):202-14
pubmed: 18191756
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Cell. 2004 Oct 15;119(2):285-98
pubmed: 15479644
Eur J Cancer. 2010 Jan;46(1):191-7
pubmed: 19857958
Am J Physiol Endocrinol Metab. 2014 Sep 15;307(6):E469-84
pubmed: 25096180
Eur J Nutr. 2013 Apr;52(3):1191-9
pubmed: 22847643
Am J Physiol Cell Physiol. 2007 Jan;292(1):C372-82
pubmed: 16928772
J Am Geriatr Soc. 2007 May;55(5):769-74
pubmed: 17493199
Int J Endocrinol. 2013;2013:907565
pubmed: 23762056
Int J Mol Sci. 2019 May 10;20(9):
pubmed: 31083375
Arthritis Rheum. 2002 Oct;46(10):2794-803
pubmed: 12384940
Bone. 2015 Nov;80:67-78
pubmed: 26453497
Cell. 2004 Apr 30;117(3):399-412
pubmed: 15109499
J Clin Biochem Nutr. 2011 Jul;49(1):8-15
pubmed: 21765600
Science. 2001 Nov 23;294(5547):1704-8
pubmed: 11679633
J Biol Chem. 2017 Aug 4;292(31):12885-12894
pubmed: 28607151
Int J Biochem Cell Biol. 2005 Oct;37(10):1962-73
pubmed: 15905114
FASEB J. 2009 Sep;23(9):2844-54
pubmed: 19406843
Biosci Biotechnol Biochem. 2016;80(4):791-7
pubmed: 26757775
Clin Geriatr Med. 2017 Aug;33(3):305-314
pubmed: 28689564

Auteurs

Aki Miyawaki (A)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.
Division of Oral and Maxillofacial Surgery, Department of Science and Physical Functions, Kyushu Dental University, Kitakyushu, Japan.

Thira Rojasawasthien (T)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Suzuro Hitomi (S)

Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.

Yoshinori Aoki (Y)

Foods and Nutrition Science Div. Mitsubishi-Chemical Foods Corporation, Tokyo, Japan.

Mariko Urata (M)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Asako Inoue (A)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Takuma Matsubara (T)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Kazumasa Morikawa (K)

Division of Pediatric and Special Care Dentistry, Department of Developmental Oral Health Science, School of Dentistry, Iwate Medical University, Morioka, Japan.

Manabu Habu (M)

Division of Oral and Maxillofacial Surgery, Department of Science and Physical Functions, Kyushu Dental University, Kitakyushu, Japan.

Kazuhiro Tominaga (K)

Division of Oral and Maxillofacial Surgery, Department of Science and Physical Functions, Kyushu Dental University, Kitakyushu, Japan.

Shoichiro Kokabu (S)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan r14kokabu@fa.kyu-dent.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Oral Administration of Geranylgeraniol Rescues...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de neurochirurgie › Dénervation › Oral Administration of Geranylgeraniol Rescues...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Oral Administration of Geranylgeraniol Rescues...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oral Administration of Geranylgeraniol Rescues...
questionsmedicales.fr › Cellules › Cellules musculaires › Fibres musculaires squelettiques › Oral Administration of Geranylgeraniol Rescues...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Oral Administration of Geranylgeraniol Rescues...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Oral Administration of Geranylgeraniol Rescues...