Testicular blood supply is altered in the 41,XX
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
06
12
2019
accepted:
10
08
2020
entrez:
3
9
2020
pubmed:
3
9
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Hypergonadotropic hypogonadism is a major feature of Klinefelter syndrome (KS), assumed to be caused by testicular hormone resistance. It was previously shown that intratesticular testosterone levels in vivo and Leydig cell function in vitro seem to be normal indicating other functional constraints. We hypothesized that impaired testicular vascularization/blood flow could be a co-factor to the observed hypergonadotropic hypogonadism. We evaluated the testicular vascular system by measuring blood vessel sizes during postnatal development and testis blood flow in adult 41,XX
Identifiants
pubmed: 32873847
doi: 10.1038/s41598-020-71377-0
pii: 10.1038/s41598-020-71377-0
pmc: PMC7462989
doi:
Substances chimiques
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14369Références
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