Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia.
Adolescent
Algeria
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Blast Crisis
/ diagnosis
Central Nervous System
/ diagnostic imaging
Female
Humans
Imatinib Mesylate
/ administration & dosage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ drug therapy
Leukemic Infiltration
/ diagnosis
Recurrence
Chronic myeloid leukemia
blast crisis
central nervous system
imatinib
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
06
2020
accepted:
19
06
2020
entrez:
3
9
2020
pubmed:
3
9
2020
medline:
23
12
2020
Statut:
epublish
Résumé
Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia chromosome t (9;22) and the BCR-ABL fusion gene. The condition is relatively rare, accounting for 2.0% to 3.0% of childhood leukemia cases. CML has historically been a triphasic disease. Most patients are diagnosed in chronic phase. Without treatment, it inevitably progresses into a more aggressive accelerated phase and blast crisis. Some proportion of CML cases of blastic transformation develop an extramedullary disease that involves rarely central nervous system. This report describe an extremely rare case of 13-year-old girl with CML and extramedullary blast crisis in the central nervous system. Treatment options and monitoring of disease response are discussed.
Identifiants
pubmed: 32874406
doi: 10.11604/pamj.2020.36.142.24155
pii: PAMJ-36-142
pmc: PMC7436633
doi:
Substances chimiques
Imatinib Mesylate
8A1O1M485B
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
142Informations de copyright
Copyright: Houda Boudiaf et al.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Blood. 1983 Jan;61(1):85-91
pubmed: 6571717
Leuk Res. 2012 Jun;36(6):e131-2
pubmed: 22444689
J Clin Oncol. 2006 Aug 20;24(24):4028-9
pubmed: 16921058
Pediatr Transplant. 2007 Sep;11(6):645-9
pubmed: 17663688
Blood. 2002 Oct 1;100(7):2292-302
pubmed: 12239137
Br J Haematol. 2002 Jun;117(3):623-5
pubmed: 12028032
Medicine (Baltimore). 2018 Nov;97(45):e13131
pubmed: 30407337
Acta Paediatr Taiwan. 2006 May-Jun;47(3):150-4
pubmed: 17078470
FDA Consum. 2001 Jul-Aug;35(4):6
pubmed: 11692893
Intern Med J. 2009 Jun;39(6):408-11
pubmed: 19580620
Pediatr Clin North Am. 2015 Feb;62(1):107-19
pubmed: 25435115
N Engl J Med. 2003 Mar 13;348(11):1048-50
pubmed: 12637616
Clin Cancer Res. 2004 Apr 1;10(7):2525-9
pubmed: 15073132
Indian J Hematol Blood Transfus. 2011 Mar;27(1):51-4
pubmed: 22379297
Blood. 2008 Aug 15;112(4):1005-12
pubmed: 18477770
Diagn Cytopathol. 2013 Mar;41(3):253-6
pubmed: 23417967