Efficacy of herbal medicine (Xuanfei Baidu decoction) combined with conventional drug in treating COVID-19:A pilot randomized clinical trial.
COVID-19
Chinese medicine
Herbal medicine
Integrative medicine
Randomized controlled trial
Journal
Integrative medicine research
ISSN: 2213-4220
Titre abrégé: Integr Med Res
Pays: Netherlands
ID NLM: 101612707
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
13
06
2020
revised:
20
07
2020
accepted:
20
07
2020
entrez:
3
9
2020
pubmed:
3
9
2020
medline:
3
9
2020
Statut:
ppublish
Résumé
The aim of this study was to evaluate the clinical efficacy of Xuanfei Baidu Decoction (XBD) combined with conventional drug therapy compared with conventional medicine alone in patients with coronavirus disease 2019 (COVID-19). Forty-two patients with COVID-19 were randomly assigned to XBD plus conventional medicine (n = 22) and conventional medicine alone (n = 20). Both groups were treated for 1 week. The primary endpoint was the disappearance rate of main symptoms (fever, cough, and fatigue). Compared with the conventional medicine, the disappearance rate of clinical symptoms such as fever, cough, fatigue and loss of appetite in the experimental group were significantly reduced (P < 0.05). The number of white blood cells and lymphocytes in the experimental group increased significantly (P < 0.05), which all returned to normal parameters. Meanwhile, the C-reactive protein and erythrocyte sedimentation rate in the experimental group were significantly reduced (P < 0.05). XBD combined with conventional medicine may significantly improve patient's clinical symptoms, increase the number of white blood cells and lymphocytes to improve immunity, and also significantly reduce C-reactive protein and erythrocyte sedimentation rate to play an anti-inflammatory effect. However, it needs to be confirmed by a large sample study. China Clinical Trial Registry (ChiCTR2000034795).
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to evaluate the clinical efficacy of Xuanfei Baidu Decoction (XBD) combined with conventional drug therapy compared with conventional medicine alone in patients with coronavirus disease 2019 (COVID-19).
METHODS
METHODS
Forty-two patients with COVID-19 were randomly assigned to XBD plus conventional medicine (n = 22) and conventional medicine alone (n = 20). Both groups were treated for 1 week. The primary endpoint was the disappearance rate of main symptoms (fever, cough, and fatigue).
RESULTS
RESULTS
Compared with the conventional medicine, the disappearance rate of clinical symptoms such as fever, cough, fatigue and loss of appetite in the experimental group were significantly reduced (P < 0.05). The number of white blood cells and lymphocytes in the experimental group increased significantly (P < 0.05), which all returned to normal parameters. Meanwhile, the C-reactive protein and erythrocyte sedimentation rate in the experimental group were significantly reduced (P < 0.05).
CONCLUSION
CONCLUSIONS
XBD combined with conventional medicine may significantly improve patient's clinical symptoms, increase the number of white blood cells and lymphocytes to improve immunity, and also significantly reduce C-reactive protein and erythrocyte sedimentation rate to play an anti-inflammatory effect. However, it needs to be confirmed by a large sample study.
CLINICAL TRIAL REGISTRATION
BACKGROUND
China Clinical Trial Registry (ChiCTR2000034795).
Identifiants
pubmed: 32874913
doi: 10.1016/j.imr.2020.100489
pii: S2213-4220(20)30121-9
pii: 100489
pmc: PMC7452296
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100489Informations de copyright
© 2020 Korea Institute of Oriental Medicine. Publishing services by Elsevier B.V.
Références
Complement Ther Clin Pract. 2020 May;39:101165
pubmed: 32379692
Chin Med. 2020 May 24;15:51
pubmed: 32483409