Zoledronic Acid in a Mouse Model of Human Fibrous Dysplasia: Ineffectiveness on Tissue Pathology, Formation of "Giant Osteoclasts" and Pathogenetic Implications.
Denosumab
Fibrous dysplasia
Giant osteoclasts
Nitrogen-containing bisphosphonates
Zoledronic acid
Journal
Calcified tissue international
ISSN: 1432-0827
Titre abrégé: Calcif Tissue Int
Pays: United States
ID NLM: 7905481
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
20
04
2020
accepted:
17
08
2020
pubmed:
3
9
2020
medline:
15
7
2021
entrez:
3
9
2020
Statut:
ppublish
Résumé
We compared the effects of a nitrogen-containing bisphosphonate (N-BP), zoledronic acid (ZA), and an anti-mouse RANKL antibody (anti-mRANKL Ab) on the bone tissue pathology of a transgenic mouse model of human fibrous dysplasia (FD). For comparison, we also reviewed the histological samples of a child with McCune-Albright syndrome (MAS) treated with Pamidronate for 3 years. EF1α-Gsα
Identifiants
pubmed: 32875378
doi: 10.1007/s00223-020-00752-w
pii: 10.1007/s00223-020-00752-w
pmc: PMC7593313
doi:
Substances chimiques
Diphosphonates
0
Zoledronic Acid
6XC1PAD3KF
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
603-610Références
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