Observation of the Sedative Effect of Dexmedetomidine Combined With Midazolam Nasal Drops Before a Pediatric Craniocerebral MRI.
Journal
The Journal of craniofacial surgery
ISSN: 1536-3732
Titre abrégé: J Craniofac Surg
Pays: United States
ID NLM: 9010410
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
entrez:
3
9
2020
pubmed:
3
9
2020
medline:
12
1
2021
Statut:
ppublish
Résumé
This study aimed to investigate the sedative effect of dexmedetomidine combined with midazolam nasal drops before a pediatric craniocerebral magnetic resonance imaging (MRI). Eighty children who needed an MRI examination were enrolled in the present study and randomly divided into 2 groups: the observation group (dexmedetomidine combined with midazolam nasal drops) and the control group. After the children were given the medication, their heart rate, blood oxygen saturation (SpO2), and respiratory rate were continuously monitored and the adverse reactions such as nausea and vomiting, cough, restlessness, heart rate slowdown, and respiratory depression were observed. The difference in the onset time between the 2 groups was not statistically significant (P > 0.05), but the duration was significantly longer in the observation group than in the control group (P < 0.01) and the examination success rate were significantly higher in the observation group than in the control group (P < 0.05). The protocol of 3 μg/kg of a dexmedetomidine injection combined with 0.3 mg/kg of midazolam nasal drops is safe, easy to operate, and has a high success rate, which is worthy of clinical promotion.
Identifiants
pubmed: 32877157
doi: 10.1097/SCS.0000000000006657
pii: 00001665-202009000-00071
doi:
Substances chimiques
Hypnotics and Sedatives
0
Dexmedetomidine
67VB76HONO
Midazolam
R60L0SM5BC
Types de publication
Journal Article
Observational Study
Randomized Controlled Trial
Langues
eng
Pagination
1796-1799Références
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