Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.

Adult Aged Bilirubin / adverse effects Case-Control Studies Colorectal Neoplasms / blood Europe Female Humans Male Mendelian Randomization Analysis / methods Middle Aged Polymorphism, Single Nucleotide Prospective Studies Risk Factors
Anti-oxidants Bilirubin Cancer Colorectal cancer Mendelian randomization analysis

Journal

BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723

Informations de publication

Date de publication:
03 09 2020
Historique:
received: 25 02 2020
accepted: 09 07 2020
entrez: 4 9 2020
pubmed: 4 9 2020
medline: 11 2 2021
Statut: epublish

Résumé

Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10 The associations between circulating UCB levels and CRC risk differed by sex (P Additional insight into the relationship between circulating bilirubin and CRC is needed in order to conclude on a potential causal role of bilirubin in CRC development.

Sections du résumé

BACKGROUND
Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex.
METHODS
In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10
RESULTS
The associations between circulating UCB levels and CRC risk differed by sex (P
CONCLUSIONS
Additional insight into the relationship between circulating bilirubin and CRC is needed in order to conclude on a potential causal role of bilirubin in CRC development.

Identifiants

DOI: 10.1186/s12916-020-01703-w PMID: 32878631 PMC: PMC7469292
pubmed: 32878631
doi: 10.1186/s12916-020-01703-w
pii: 10.1186/s12916-020-01703-w
pmc: PMC7469292
doi:

Substances chimiques

Bilirubin RFM9X3LJ49

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

229

Subventions

Organisme : NCI NIH HHS
ID : R01 CA201407
Pays : United States
Organisme : Cancer Research UK
ID : 25004
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167551
Pays : United States

Références

Aliment Pharmacol Ther. 2006 Jun 1;23(11):1637-42
pubmed: 16696814
Gut. 2017 Apr;66(4):683-691
pubmed: 26818619
Public Health Nutr. 2002 Dec;5(6B):1113-24
pubmed: 12639222
Cancer Genet. 2012 Apr;205(4):163-7
pubmed: 22559977
J Biol Chem. 1999 Apr 16;274(16):10852-62
pubmed: 10196162
Eur J Clin Invest. 2013 Sep;43(9):912-9
pubmed: 23865893
Stat Med. 2017 May 20;36(11):1783-1802
pubmed: 28114746
Int J Cancer. 2012 Oct 1;131(7):1549-55
pubmed: 22212955
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
Gastroenterology. 2013 Apr;144(4):799-807.e24
pubmed: 23266556
Gastroenterology. 1984 Aug;87(2):308-13
pubmed: 6428963
Int J Epidemiol. 2019 Jun 1;48(3):691-701
pubmed: 30325422
Cancer Causes Control. 2001 Dec;12(10):887-94
pubmed: 11808707
J Hepatol. 2003 Jan;38(1):107-17
pubmed: 12480568
Sci Rep. 2017 Apr 7;7(1):755
pubmed: 28389660
Liver Int. 2008 May;28(5):592-605
pubmed: 18433389
Blood Rev. 2014 Mar;28(2):41-7
pubmed: 24491804
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Epidemiology. 2010 Jan;21(1):13-5
pubmed: 20010207
Clin Sci (Lond). 2013 Sep;125(5):257-64
pubmed: 23566065
Int J Epidemiol. 2017 Dec 1;46(6):1985-1998
pubmed: 29040600
Mutat Res. 2008 Sep 26;644(1-2):56-63
pubmed: 18675828
Nat Commun. 2014 Aug 08;5:4613
pubmed: 25105248
Br J Cancer. 2017 Nov 7;117(10):1572-1579
pubmed: 28898231
Bioinformatics. 2020 Jan 15;36(2):649-650
pubmed: 31373609
Drug Metab Dispos. 2009 Apr;37(4):834-40
pubmed: 19131521
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5171-6
pubmed: 19286972
Atherosclerosis. 2018 Feb;269:306-311
pubmed: 29279144
Antioxid Redox Signal. 2004 Oct;6(5):841-9
pubmed: 15345144
Sci Rep. 2018 Jan 31;8(1):2008
pubmed: 29386646
World J Gastroenterol. 2012 May 7;18(17):2005-8
pubmed: 22563186
Genet Epidemiol. 2016 Nov;40(7):597-608
pubmed: 27625185
Am J Epidemiol. 2006 Jun 1;163(11):1053-64
pubmed: 16624970
J Hepatol. 2002 Mar;36(3):335-41
pubmed: 11867176
Int J Epidemiol. 2011 Jun;40(3):755-64
pubmed: 21414999
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Nat Immunol. 2016 Mar;17(3):230-40
pubmed: 26882261
Nat Genet. 2019 Jan;51(1):76-87
pubmed: 30510241
Stat Med. 2016 May 20;35(11):1880-906
pubmed: 26661904
BMJ. 2010 Jan 21;340:b5500
pubmed: 20093284
Int J Cancer. 2004 Nov 10;112(3):433-45
pubmed: 15382069
Int J Epidemiol. 1997;26 Suppl 1:S6-14
pubmed: 9126529
Hepatology. 2004 Oct;40(4):827-35
pubmed: 15382174
Free Radic Res. 2012 Nov;46(11):1369-77
pubmed: 22861140
Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2331-43
pubmed: 17982118
Carcinogenesis. 2004 Dec;25(12):2407-15
pubmed: 15319294
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Biochem J. 2009 Jan 1;417(1):305-12
pubmed: 18713069
Crit Rev Clin Lab Sci. 2018 Mar;55(2):129-139
pubmed: 29390925
Biochem Biophys Res Commun. 2006 Apr 21;342(4):1279-83
pubmed: 16516158
Clin Sci (Lond). 2015 Jul;129(1):1-25
pubmed: 25881719
J Natl Cancer Inst. 2019 Feb 1;111(2):146-157
pubmed: 29917119
Science. 1987 Feb 27;235(4792):1043-6
pubmed: 3029864
Curr Epidemiol Rep. 2017;4(4):330-345
pubmed: 29226067
World J Gastroenterol. 2005 Jun 7;11(21):3250-4
pubmed: 15929176
J Hepatol. 2002 Jan;36(1):72-7
pubmed: 11804667
Lancet. 2012 Mar 31;379(9822):1173-4
pubmed: 22463865
Hum Mol Genet. 2018 Aug 1;27(R2):R195-R208
pubmed: 29771313
Pediatr Res. 1996 Jun;39(6):1072-7
pubmed: 8725272
Rinsho Byori. 1992 Jun;40(6):673-8
pubmed: 1513041

Auteurs

Nazlisadat Seyed Khoei (N)

Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

Mazda Jenab (M)

Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Neil Murphy (N)

Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Barbara L Banbury (BL)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Robert Carreras-Torres (R)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.

Vivian Viallon (V)

Nutritional Methodology and Biostatistics Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France.

Tilman Kühn (T)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Bas Bueno-de-Mesquita (B)

Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands.
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Krasimira Aleksandrova (K)

Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

Amanda J Cross (AJ)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Elisabete Weiderpass (E)

International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Magdalena Stepien (M)

Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Andrew Bulmer (A)

School of Medicine, Griffith University, Brisbane, QLD, Australia.
Alliance for Vascular Access Teaching and Research (AVATAR), Menzies Health Institute Queensland, Griffith University, Brisbane, QLD, Australia.

Anne Tjønneland (A)

Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Marie-Christine Boutron-Ruault (MC)

CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.
Institut Gustave Roussy, Villejuif, France.

Gianluca Severi (G)

CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.
Institut Gustave Roussy, Villejuif, France.

Franck Carbonnel (F)

CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.
Institut Gustave Roussy, Villejuif, France.
Department of Gastroenterology, Bicêtre University Hospital, Public Assistance Hospitals of Paris, Le Kremlin Bicêtre, France.

Verena Katzke (V)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Heiner Boeing (H)

Department of Epidemiology, German Institute of Human Nutrition Postdam-Rehbrücke, Nuthetal, Germany.

Manuela M Bergmann (MM)

Department of Epidemiology, German Institute of Human Nutrition Postdam-Rehbrücke, Nuthetal, Germany.

Antonia Trichopoulou (A)

Hellenic Health Foundation, Athens, Greece.

Anna Karakatsani (A)

Hellenic Health Foundation, Athens, Greece.
2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece.

Georgia Martimianaki (G)

Hellenic Health Foundation, Athens, Greece.

Domenico Palli (D)

Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.

Giovanna Tagliabue (G)

Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Salvatore Panico (S)

Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.

Rosario Tumino (R)

Cancer Registry and Histopathology Department, "M.P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy.

Carlotta Sacerdote (C)

Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy.

Guri Skeie (G)

Department of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT), The Arctic University of Norway, Tromsø, Norway.
Nutritional Epidemiology Group, School of Food and Nutrition, University of Leeds, Leeds, UK.

Susana Merino (S)

Public Health Directorate, Asturias, Spain.

Catalina Bonet (C)

Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.

Miguel Rodríguez-Barranco (M)

Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria, ibs. GRANADA, Universidad de Granada, Granada, Spain.
CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Leire Gil (L)

Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian, Spain.

Maria-Dolores Chirlaque (MD)

CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain.

Eva Ardanaz (E)

CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Navarra Public Health Institute, Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.

Robin Myte (R)

Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.

Johan Hultdin (J)

Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.

Aurora Perez-Cornago (A)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Dagfinn Aune (D)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Nutrition, Bjørknes University College, Oslo, Norway.
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.

Konstantinos K Tsilidis (KK)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

John A Baron (JA)

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Stéphane Bézieau (S)

Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Peter T Campbell (PT)

Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.

Graham Casey (G)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

Andrew T Chan (AT)

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Michelle Cotterchio (M)

Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

Steven Gallinger (S)

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Stephen B Gruber (SB)

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Robert W Haile (RW)

Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA.

Jochen Hampe (J)

Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.

Michael Hoffmeister (M)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

John L Hopper (JL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea.

Li Hsu (L)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.

Jeroen R Huyghe (JR)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Mark A Jenkins (MA)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Amit D Joshi (AD)

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Ellen Kampman (E)

Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands.

Susanna C Larsson (SC)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Loic Le Marchand (L)

University of Hawaii Cancer Center, Honolulu, HI, USA.

Christopher I Li (CI)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Li Li (L)

Department of Family Medicine, University of Virginia, Charlottesville, VA, USA.

Annika Lindblom (A)

Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Noralane M Lindor (NM)

Department of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.

Vicente Martín (V)

CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Biomedicine Institute (IBIOMED), University of León, León, Spain.

Victor Moreno (V)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.
Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.

Polly A Newcomb (PA)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Kenneth Offit (K)

Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA.
Department of Medicine, Weill Cornell Medical College, New York, USA.

Shuji Ogino (S)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.

Patrick S Parfrey (PS)

The Clinical Epidemiology Unit, Memorial University Medical School, Newfoundland, Canada.

Paul D P Pharoah (PDP)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Gad Rennert (G)

Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Clalit National Cancer Control Center, Haifa, Israel.

Lori C Sakoda (LC)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Clemens Schafmayer (C)

Department of General, Visceral, Vascular, and Transplantation Surgery, University Hospital Rostock, Rostock, Germany.

Stephanie L Schmit (SL)

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Robert E Schoen (RE)

Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Martha L Slattery (ML)

Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.

Stephen N Thibodeau (SN)

Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Cornelia M Ulrich (CM)

Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.

Franzel J B van Duijnhoven (FJB)

Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands.

Korbinian Weigl (K)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Medical Faculty, University of Heidelberg, Heidelberg, Germany.

Stephanie J Weinstein (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Emily White (E)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Michael O Woods (MO)

Discipline of Genetics, Memorial University of Newfoundland, St. John's, Canada.

Anna H Wu (AH)

University of Southern California, Preventative Medicine, Los Angeles, CA, USA.

Xuehong Zhang (X)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Pietro Ferrari (P)

Nutritional Methodology and Biostatistics Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France.

Gabriele Anton (G)

Institute of Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany.

Ulrike Peters (U)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Marc J Gunter (MJ)

Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.

Karl-Heinz Wagner (KH)

Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

Heinz Freisling (H)

Nutritional Methodology and Biostatistics Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France. freislingh@iarc.fr.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Pigments biliaires › Bilirubine › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Régions géographiques › Europe › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Circulating bilirubin levels and risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Circulating bilirubin levels and risk of...