Fear Deficits in Hypomyelinated
fear
microtubule
myelin
oligodendrocyte
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
Historique:
received:
29
04
2020
revised:
03
06
2020
accepted:
09
07
2020
pubmed:
4
9
2020
medline:
22
6
2021
entrez:
4
9
2020
Statut:
epublish
Résumé
Oligodendrocytes in the central nervous system (CNS) produce myelin sheaths that insulate axons to facilitate efficient electrical conduction. These myelin sheaths contain lamellar microtubules that enable vesicular transport into the inner sheath. Mechanistically, oligodendrocytes rely on Golgi outpost organelles and the associated protein tubulin polymerization promoting protein (TPPP) to nucleate or form new microtubules outside of the cell body. Consequently, elongation of lamellar microtubules is defective in
Identifiants
pubmed: 32878961
pii: ENEURO.0170-20.2020
doi: 10.1523/ENEURO.0170-20.2020
pmc: PMC7540923
pii:
doi:
Substances chimiques
Nerve Tissue Proteins
0
TPPP protein, mouse
0
Tubulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Nguyen et al.
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