Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins.
X-ray crystallography
crystal structure
encapsulated ferritin
encapsulin
ferritin
ferroxidase
iron
iron metabolism
mass spectrometry (MS)
native mass spectrometry
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
13 11 2020
13 11 2020
Historique:
received:
25
05
2020
revised:
24
08
2020
pubmed:
4
9
2020
medline:
10
3
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Encapsulated ferritins belong to the universally distributed ferritin superfamily, whose members function as iron detoxification and storage systems. Encapsulated ferritins have a distinct annular structure and must associate with an encapsulin nanocage to form a competent iron store that is capable of holding significantly more iron than classical ferritins. The catalytic mechanism of iron oxidation in the ferritin family is still an open question because of the differences in organization of the ferroxidase catalytic site and neighboring secondary metal-binding sites. We have previously identified a putative metal-binding site on the inner surface of the
Identifiants
pubmed: 32878987
pii: S0021-9258(17)50385-3
doi: 10.1074/jbc.RA120.014502
pmc: PMC7667983
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Metals
0
Recombinant Proteins
0
Iron
E1UOL152H7
Ceruloplasmin
EC 1.16.3.1
Zinc
J41CSQ7QDS
Banques de données
PDB
['5DA5']
figshare
['10.6084/m9.figshare.11920512']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15511-15526Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N005570/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M010996/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098375/Z/12/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R013942/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R013993/1
Pays : United Kingdom
Informations de copyright
© 2020 Piergentili et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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